The widespread regulation of microRNA biogenesis, function and decay

• Published in: Nature reviews. Genetics Vol. 11; no. 9; pp. 597 - 610
• Main Authors: Krol, Jacek, Loedige, Inga, Filipowicz, Witold
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2010; Nature Publishing Group
• Subjects: 631/208/200; 631/337/1645; 631/337/384/331; Agriculture; Animal Genetics and Genomics; Animals; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Biosynthesis; Cancer Research; Cytoplasm; Enzymes; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation; Gene Function; Genetics of eukaryotes. Biological and molecular evolution; Human Genetics; Humans; Metabolism; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Physiological aspects; Protein biosynthesis; Proteins; review-article; RNA; RNA polymerase; RNA Stability; United States; Gene silencing; Regulation(control); RNA interference; Review; Biogenesis; Micro RNA

Key Points MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that control many developmental and cellular processes in eukaryotic organisms. Recent research indicates that miRNA regulators themselves are subject to sophisticated control at the levels of miRN...