Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters

No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of re...

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Published inTranslational psychiatry Vol. 10; no. 1; p. 342
Main Authors Bruin, Willem B., Taylor, Luke, Thomas, Rajat M., Shock, Jonathan P., Zhutovsky, Paul, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H., Anticevic, Alan, Arnold, Paul D., Assogna, Francesca, Benedetti, Francesco, Beucke, Jan C., Boedhoe, Premika S. W., Bollettini, Irene, Bose, Anushree, Brem, Silvia, Brennan, Brian P., Buitelaar, Jan K., Calvo, Rosa, Cheng, Yuqi, Cho, Kang Ik K., Dallaspezia, Sara, Denys, Damiaan, Ely, Benjamin A., Feusner, Jamie D., Fitzgerald, Kate D., Fouche, Jean-Paul, Fridgeirsson, Egill A., Gruner, Patricia, Gürsel, Deniz A., Hauser, Tobias U., Hirano, Yoshiyuki, Hoexter, Marcelo Q., Hu, Hao, Huyser, Chaim, Ivanov, Iliyan, James, Anthony, Jaspers-Fayer, Fern, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Kuno, Masaru, Kvale, Gerd, Kwon, Jun Soo, Liu, Yanni, Lochner, Christine, Lázaro, Luisa, Marques, Paulo, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José M., Minuzzi, Luciano, Moreira, Pedro S., Morer, Astrid, Morgado, Pedro, Nakagawa, Akiko, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C., Nurmi, Erika L., O’Neill, Joseph, Pariente, Jose C., Perriello, Chris, Piacentini, John, Piras, Fabrizio, Piras, Federica, Reddy, Y. C. Janardhan, Rus-Oswald, Oana G., Sakai, Yuki, Sato, João R., Schmaal, Lianne, Shimizu, Eiji, Simpson, H. Blair, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Stern, Emily R., Stevens, Michael C., Stewart, S. Evelyn, Szeszko, Philip R., Tolin, David F., Venkatasubramanian, Ganesan, Wang, Zhen, Yun, Je-Yeon, van Rooij, Daan, Thompson, Paul M., van den Heuvel, Odile A., Stein, Dan J., van Wingen, Guido A.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 08.10.2020
Subjects
59/57
631/378
692/53/2421
Behavioral Sciences
Biological Psychology
Biomarkers
Brain - diagnostic imaging
Humans
Magnetic Resonance Imaging
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Neuroimaging
Neurosciences
Obsessive-Compulsive Disorder - diagnostic imaging
Obsessive-Compulsive Disorder - drug therapy
Pharmacotherapy
Psychiatry
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Abstract No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures of cortical thickness, surface area and subcortical volume and tested classification performance using cross-validation. Classification performance for OCD vs. controls using the complete sample with different classifiers and cross-validation strategies was poor. When models were validated on data from other sites, model performance did not exceed chance-level. In contrast, fair classification performance was achieved when patients were grouped according to their medication status. These results indicate that medication use is associated with substantial differences in brain anatomy that are widely distributed, and indicate that clinical heterogeneity contributes to the poor performance of structural MRI as a disease marker.
AbstractList No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures of cortical thickness, surface area and subcortical volume and tested classification performance using cross-validation. Classification performance for OCD vs. controls using the complete sample with different classifiers and cross-validation strategies was poor. When models were validated on data from other sites, model performance did not exceed chance-level. In contrast, fair classification performance was achieved when patients were grouped according to their medication status. These results indicate that medication use is associated with substantial differences in brain anatomy that are widely distributed, and indicate that clinical heterogeneity contributes to the poor performance of structural MRI as a disease marker.
ArticleNumber 342
Author Perriello, Chris
Nakagawa, Akiko
James, Anthony
Kvale, Gerd
Lochner, Christine
Wang, Zhen
Nurmi, Erika L.
Menchón, José M.
Ely, Benjamin A.
Kaufmann, Christian
van Rooij, Daan
Hoexter, Marcelo Q.
Denys, Damiaan
Szeszko, Philip R.
Taylor, Luke
Hu, Hao
Koch, Kathrin
Fitzgerald, Kate D.
Morgado, Pedro
Stein, Dan J.
Alonso, Pino
Sato, João R.
Liu, Yanni
Yun, Je-Yeon
Simpson, H. Blair
Sakai, Yuki
Hirano, Yoshiyuki
Gürsel, Deniz A.
Dallaspezia, Sara
Calvo, Rosa
Beucke, Jan C.
Schmaal, Lianne
van den Heuvel, Odile A.
Soriano-Mas, Carles
Stern, Emily R.
Bollettini, Irene
Cho, Kang Ik K.
Gruner, Patricia
Venkatasubramanian, Ganesan
Kuno, Masaru
Piras, Fabrizio
Jaspers-Fayer, Fern
Nakao, Tomohiro
Stewart, S. Evelyn
Soreni, Noam
Nakamae, Takashi
Narayanaswamy, Janardhanan C.
Huyser, Chaim
Stevens, Michael C.
Fridgeirsson, Egill A.
van Wingen, Guido A.
Piacentini, John
Ameis, Stephanie H.
Anticevic, Alan
Cheng, Yuqi
Morer, Astrid
Arnold, Paul D.
Brennan, Brian P.
Mataix-Cols, David
Fouche, Jean-Paul
Benedetti, Francesco
Bruin, Willem B.
Hauser, Tobias U.
Thom
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ContentType Journal Article
Contributor Hanna, Gregory L
Xu, Xiufeng
van Wingen, Guido A
Ciullo, Valentina
Figee, Martijn
Poletti, Sara
Drechsler, Renate
Gueguen, Margot
Sousa, Nuno
Walitza, Susanne
Xu, Jian
Busatto, Geraldo F
Fang, Yu
Vecchio, Daniela
Brandeis, Daniel
Yoshida, Tokiko
Fontaine, Martine
van Rooij, Daan
Esteves, Madalena
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Snippet No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD,...
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SubjectTerms 59/57
631/378
692/53/2421
Behavioral Sciences
Biological Psychology
Biomarkers
Brain - diagnostic imaging
Humans
Magnetic Resonance Imaging
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Neuroimaging
Neurosciences
Obsessive-Compulsive Disorder - diagnostic imaging
Obsessive-Compulsive Disorder - drug therapy
Pharmacotherapy
Psychiatry
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Title Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters
URI https://link.springer.com/article/10.1038/s41398-020-01013-y
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