Glutathione Redox System in β-Thalassemia/Hb E Patients

• Published in: TheScientificWorld Vol. 2013; no. 2013; pp. 1 - 7
• Main Authors: Siritanaratkul, Noppadol, Panichkul, Narumol, Charoensakdi, Ratiya, Hatairaktham, Suneerat, Tangjaidee, Thongchai, Kalpravidh, Ruchaneekorn W., Fucharoen, Suthat
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2013; John Wiley & Sons, Inc; Wiley
• Subjects: Acids; Anemia; Antioxidants; beta-Thalassemia - blood; beta-Thalassemia - metabolism; beta-Thalassemia - surgery; Biochemistry; Blood; Case-Control Studies; Correlation; Enzymatic activity; Enzymes; Female; Ferritin; Ferritins - blood; Glutathione; Glutathione - blood; Glutathione Disulfide - blood; Health aspects; Hematology; Hemoglobin; Hemoglobin E - analysis; Homeostasis; Humans; Iron; Male; Oxidation; Oxidation-Reduction; Oxidation-reduction reaction; Oxidative stress; Patients; Physiological aspects; Protein research; Sensors; Splenectomy; Thalassemia; Thailand; United States > US

β-thalassemia/Hb E is known to cause oxidative stress induced by iron overload. The glutathione system is the major endogenous antioxidant that protects animal cells from oxidative damage. This study aimed to determine the effect of disease state and splenectomy on redox status expressed by whole bl...