Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus

• Published in: Antiviral research Vol. 81; no. 1; pp. 77 - 81
• Main Authors: Choi, Hwa-Jung, Kim, Jin-Hee, Lee, Choong-Hwan, Ahn, Young-Joon, Song, Jae-Hyoung, Baek, Seung-Hwa, Kwon, Dur-Han
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01.01.2009; Elsevier
• Subjects: Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral activity; Antiviral agents; Antiviral Agents - pharmacology; Biological and medical sciences; Chlorocebus aethiops; Diarrhea - drug therapy; Diarrhea - veterinary; Diarrhea - virology; Flavonoids - pharmacology; Houttuynia cordat; Medical sciences; Pharmacology. Drug treatments; Porcine epidemic diarrhea virus; Porcine epidemic diarrhea virus - drug effects; Porcine epidemic diarrhea virus - genetics; Quercetin - analogs & derivatives; Quercetin - pharmacology; Quercetin 7-rhamnoside; Structure-Activity Relationship; Swine Diseases - drug therapy; Swine Diseases - virology; Vero Cells; Virus Replication - drug effects; Porcine epidemic diarrhea virus; Houttuynia cordat; Quercetin 7-rhamnoside; Antiviral activity; Flavonoid; Virus; Polyphenol; Saururaceae; Coronavirus; Treatment; Structure activity relation; Dicotyledones; Angiospermae; Quercetin; Phenols; Antiviral; Spermatophyta; Coronaviridae; Veterinary; Mechanism of action; Nidovirales

Porcine epidemic diarrhea virus (PEDV) is the predominant cause of severe entero-pathogenic diarrhea in swine. The lack of effective therapeutical treatment underlines the importance of research for new antivirals. In this study, we identified Q7R, which actively inhibited PEDV replication with a 50...