Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus
Porcine epidemic diarrhea virus (PEDV) is the predominant cause of severe entero-pathogenic diarrhea in swine. The lack of effective therapeutical treatment underlines the importance of research for new antivirals. In this study, we identified Q7R, which actively inhibited PEDV replication with a 50...
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| Published in | Antiviral research Vol. 81; no. 1; pp. 77 - 81 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Kidlington
Elsevier B.V
01.01.2009
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Porcine epidemic diarrhea virus (PEDV) is the predominant cause of severe entero-pathogenic diarrhea in swine. The lack of effective therapeutical treatment underlines the importance of research for new antivirals. In this study, we identified Q7R, which actively inhibited PEDV replication with a 50% inhibitory concentration (IC
50) of 0.014
μg/mL. The 50% cytotoxicity concentration (CC
50) of Q7R was over 100
μg/mL and the derived therapeutic index was 7142. Several structural analogues of Q7R, quercetin, apigenin, luteolin and catechin, also showed moderate anti-PEDV activity. Antiviral drugs and natural compounds revealed ribavirin, interferon-α, coumarin and tannic acid have relative weaker efficacy compared to Q7R. Q7R did not directly interact with or inactivate PEDV particles and affect the initial stage of PEDV infection by interfering of PEDV replication. Also, the effectiveness of Q7R against the other two viruses (TGEV, PRCV) was lower compared to PEDV. Q7R could be considered as a lead compound for development of anti-PEDV drugs to may be used to during the early stage of PEDV replication and the structure-activity data of Q7R may usefully guideline to design other related antiviral agents. |
|---|---|
| AbstractList | Porcine epidemic diarrhea virus (PEDV) is the predominant cause of severe entero-pathogenic diarrhea in swine. The lack of effective therapeutical treatment underlines the importance of research for new antivirals. In this study, we identified Q7R, which actively inhibited PEDV replication with a 50% inhibitory concentration (IC
50) of 0.014
μg/mL. The 50% cytotoxicity concentration (CC
50) of Q7R was over 100
μg/mL and the derived therapeutic index was 7142. Several structural analogues of Q7R, quercetin, apigenin, luteolin and catechin, also showed moderate anti-PEDV activity. Antiviral drugs and natural compounds revealed ribavirin, interferon-α, coumarin and tannic acid have relative weaker efficacy compared to Q7R. Q7R did not directly interact with or inactivate PEDV particles and affect the initial stage of PEDV infection by interfering of PEDV replication. Also, the effectiveness of Q7R against the other two viruses (TGEV, PRCV) was lower compared to PEDV. Q7R could be considered as a lead compound for development of anti-PEDV drugs to may be used to during the early stage of PEDV replication and the structure-activity data of Q7R may usefully guideline to design other related antiviral agents. Porcine epidemic diarrhea virus (PEDV) is the predominant cause of severe entero-pathogenic diarrhea in swine. The lack of effective therapeutical treatment underlines the importance of research for new antivirals. In this study, we identified Q7R, which actively inhibited PEDV replication with a 50% inhibitory concentration (IC sub(5) sub(0)) of 0.014kg/mL. The 50% cytotoxicity concentration (CC sub(5) sub(0)) of Q7R was over 100kg/mL and the derived therapeutic index was 7142. Several structural analogues of Q7R, quercetin, apigenin, luteolin and catechin, also showed moderate anti-PEDV activity. Antiviral drugs and natural compounds revealed ribavirin, interferon-a, coumarin and tannic acid have relative weaker efficacy compared to Q7R. Q7R did not directly interact with or inactivate PEDV particles and affect the initial stage of PEDV infection by interfering of PEDV replication. Also, the effectiveness of Q7R against the other two viruses (TGEV, PRCV) was lower compared to PEDV. Q7R could be considered as a lead compound for development of anti-PEDV drugs to may be used to during the early stage of PEDV replication and the structure-activity data of Q7R may usefully guideline to design other related antiviral agents. Porcine epidemic diarrhea virus (PEDV) is the predominant cause of severe entero-pathogenic diarrhea in swine. The lack of effective therapeutical treatment underlines the importance of research for new antivirals. In this study, we identified Q7R, which actively inhibited PEDV replication with a 50% inhibitory concentration (IC(50)) of 0.014 microg/mL. The 50% cytotoxicity concentration (CC(50)) of Q7R was over 100 microg/mL and the derived therapeutic index was 7142. Several structural analogues of Q7R, quercetin, apigenin, luteolin and catechin, also showed moderate anti-PEDV activity. Antiviral drugs and natural compounds revealed ribavirin, interferon-alpha, coumarin and tannic acid have relative weaker efficacy compared to Q7R. Q7R did not directly interact with or inactivate PEDV particles and affect the initial stage of PEDV infection by interfering of PEDV replication. Also, the effectiveness of Q7R against the other two viruses (TGEV, PRCV) was lower compared to PEDV. Q7R could be considered as a lead compound for development of anti-PEDV drugs to may be used to during the early stage of PEDV replication and the structure-activity data of Q7R may usefully guideline to design other related antiviral agents. Porcine epidemic diarrhea virus (PEDV) is the predominant cause of severe entero-pathogenic diarrhea in swine. The lack of effective therapeutical treatment underlines the importance of research for new antivirals. In this study, we identified Q7R, which actively inhibited PEDV replication with a 50% inhibitory concentration (IC 50 ) of 0.014 μg/mL. The 50% cytotoxicity concentration (CC 50 ) of Q7R was over 100 μg/mL and the derived therapeutic index was 7142. Several structural analogues of Q7R, quercetin, apigenin, luteolin and catechin, also showed moderate anti-PEDV activity. Antiviral drugs and natural compounds revealed ribavirin, interferon-α, coumarin and tannic acid have relative weaker efficacy compared to Q7R. Q7R did not directly interact with or inactivate PEDV particles and affect the initial stage of PEDV infection by interfering of PEDV replication. Also, the effectiveness of Q7R against the other two viruses (TGEV, PRCV) was lower compared to PEDV. Q7R could be considered as a lead compound for development of anti-PEDV drugs to may be used to during the early stage of PEDV replication and the structure-activity data of Q7R may usefully guideline to design other related antiviral agents. |
| Author | Kim, Jin-Hee Ahn, Young-Joon Choi, Hwa-Jung Baek, Seung-Hwa Kwon, Dur-Han Song, Jae-Hyoung Lee, Choong-Hwan |
| Author_xml | – sequence: 1 givenname: Hwa-Jung surname: Choi fullname: Choi, Hwa-Jung organization: Natural Medicines Research Centre, Korea Research Institute of Bioscience & Biotechnology, Taejon 305–333, Republic of Korea – sequence: 2 givenname: Jin-Hee surname: Kim fullname: Kim, Jin-Hee organization: Natural Medicines Research Centre, Korea Research Institute of Bioscience & Biotechnology, Taejon 305–333, Republic of Korea – sequence: 3 givenname: Choong-Hwan surname: Lee fullname: Lee, Choong-Hwan organization: Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea – sequence: 4 givenname: Young-Joon surname: Ahn fullname: Ahn, Young-Joon organization: School of Agricultural Biotechnology, Seoul National University, Seoul 151–921, Republic of Korea – sequence: 5 givenname: Jae-Hyoung surname: Song fullname: Song, Jae-Hyoung organization: Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 570-749, Republic of Korea – sequence: 6 givenname: Seung-Hwa surname: Baek fullname: Baek, Seung-Hwa organization: Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 570-749, Republic of Korea – sequence: 7 givenname: Dur-Han surname: Kwon fullname: Kwon, Dur-Han email: dhkwon@kribb.re.kr organization: Natural Medicines Research Centre, Korea Research Institute of Bioscience & Biotechnology, Taejon 305–333, Republic of Korea |
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| Copyright | 2008 Elsevier B.V. 2009 INIST-CNRS Copyright © 2008 Elsevier B.V. All rights reserved. 2008 Elsevier B.V. |
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| Keywords | Porcine epidemic diarrhea virus Houttuynia cordat Quercetin 7-rhamnoside Antiviral activity Flavonoid Virus Polyphenol Saururaceae Coronavirus Treatment Structure activity relation Dicotyledones Angiospermae Quercetin Phenols Antiviral Spermatophyta Coronaviridae Veterinary Mechanism of action Nidovirales |
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| Snippet | Porcine epidemic diarrhea virus (PEDV) is the predominant cause of severe entero-pathogenic diarrhea in swine. The lack of effective therapeutical treatment... |
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| SubjectTerms | Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral activity Antiviral agents Antiviral Agents - pharmacology Biological and medical sciences Chlorocebus aethiops Diarrhea - drug therapy Diarrhea - veterinary Diarrhea - virology Flavonoids - pharmacology Houttuynia cordat Medical sciences Pharmacology. Drug treatments Porcine epidemic diarrhea virus Porcine epidemic diarrhea virus - drug effects Porcine epidemic diarrhea virus - genetics Quercetin - analogs & derivatives Quercetin - pharmacology Quercetin 7-rhamnoside Structure-Activity Relationship Swine Diseases - drug therapy Swine Diseases - virology Vero Cells Virus Replication - drug effects |
| Title | Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus |
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