Pheochromocytoma Is Characterized by Catecholamine-Mediated Myocarditis, Focal and Diffuse Myocardial Fibrosis, and Myocardial Dysfunction

• Published in: Journal of the American College of Cardiology Vol. 67; no. 20; pp. 2364 - 2374
• Main Authors: Ferreira, Vanessa M., Marcelino, Mafalda, Piechnik, Stefan K., Marini, Claudia, Karamitsos, Theodoros D., Ntusi, Ntobeko A.B., Francis, Jane M., Robson, Matthew D., Arnold, J. Ranjit, Mihai, Radu, Thomas, Julia D.J., Herincs, Maria, Hassan-Smith, Zaki K., Greiser, Andreas, Arlt, Wiebke, Korbonits, Márta, Karavitaki, Niki, Grossman, Ashley B., Wass, John A.H., Neubauer, Stefan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.05.2016; Elsevier Limited
• Subjects: Adrenal Gland Neoplasms - complications; Adrenal Gland Neoplasms - metabolism; Adrenal Gland Neoplasms - surgery; cardiac magnetic resonance; Cardiology; Cardiomyopathy; Cardiovascular; Case-Control Studies; catecholamine toxicity; Catecholamines - metabolism; Colleges & universities; Diastole; Endocrinology; Female; Fibrosis; Genotype & phenotype; Heart - diagnostic imaging; Heart attacks; Heart failure; Humans; Hypertension; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Mortality; Myocarditis - etiology; Myocardium - pathology; Pericardial Effusion - etiology; Pheochromocytoma - complications; Pheochromocytoma - metabolism; Pheochromocytoma - surgery; Prospective Studies; Stroke Volume; Systole; T1 mapping; Variance analysis; Ventricular Dysfunction, Left - etiology; LVEF; CMR; LV; IQR; LGE; cardiac magnetic resonance; catecholamine toxicity; T1 mapping; LVH; interquartile range; left ventricular ejection fraction; T 1 mapping; left ventricular hypertrophy; late gadolinium enhancement; left ventricular; T mapping

Pheochromocytoma is associated with catecholamine-induced cardiac toxicity, but the extent and nature of cardiac involvement in clinical cohorts is not well-characterized. This study characterized the cardiac phenotype in patients with pheochromocytoma using cardiac magnetic resonance (CMR). A total...