Modulation of IL-37 expression by triptolide and triptonide in THP-1 cells
IL-37 is an anti-inflammatory cytokine that was only recently identified, and it is highly expressed in tissues from patients with inflammatory and autoimmune diseases. Inflammatory cytokines and inflammatory stimuli can induce the upregulation of IL-37. However, it has not been reported whether ant...
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| Published in | Cellular & molecular immunology Vol. 12; no. 4; pp. 515 - 518 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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London
Nature Publishing Group UK
01.07.2015
Nature Publishing Group |
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| Abstract | IL-37 is an anti-inflammatory cytokine that was only recently identified, and it is highly expressed in tissues from patients with inflammatory and autoimmune diseases. Inflammatory cytokines and inflammatory stimuli can induce the upregulation of IL-37. However, it has not been reported whether anti-inflammatory medications induce the expression of IL-37. In this work, we uncovered, for the first time, that two main bioactive components, triptolide and triptonide, from the herb Tripterygium wilfordii Hook f. （TwHF）, which possess anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERKI/2 and p38 MAPK inhibitors. Overall, our research demonstrated, for the first time, that anti-inflammatory active components （triptolide and triptonide） upregulated the expression of IL-37 most likely via activation of the ERKI/2 and p38 MAPK pathways. |
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| AbstractList | IL-37 is an anti-inflammatory cytokine that was only recently identified, and it is highly expressed in tissues from patients with inflammatory and autoimmune diseases. Inflammatory cytokines and inflammatory stimuli can induce the upregulation of IL-37. However, it has not been reported whether anti-inflammatory medications induce the expression of IL-37. In this work, we uncovered, for the first time, that two main bioactive components, triptolide and triptonide, from the herb Tripterygium wilfordii Hook f. (TwHF), which possess anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERK1/2 and p38 MAPK inhibitors. Overall, our research demonstrated, for the first time, that anti-inflammatory active components (triptolide and triptonide) upregulated the expression of IL-37 most likely via activation of the ERK1/2 and p38 MAPK pathways.Cellular & Molecular Immunology advance online publication, 6 October 2014; doi:10.1038/cmi.2014.92. IL-37 is an anti-inflammatory cytokine that was only recently identified, and it is highly expressed in tissues from patients with inflammatory and autoimmune diseases. Inflammatory cytokines and inflammatory stimuli can induce the upregulation of IL-37. However, it has not been reported whether anti-inflammatory medications induce the expression of IL-37. In this work, we uncovered, for the first time, that two main bioactive components, triptolide and triptonide, from the herb Tripterygium wilfordii Hook f. (TwHF), which possess anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERK1/2 and p38 MAPK inhibitors. Overall, our research demonstrated, for the first time, that anti-inflammatory active components (triptolide and triptonide) upregulated the expression of IL-37 most likely via activation of the ERK1/2 and p38 MAPK pathways. IL-37 is an anti-inflammatory cytokine that was only recently identified, and it is highly expressed in tissues from patients with inflammatory and autoimmune diseases. Inflammatory cytokines and inflammatory stimuli can induce the upregulation of IL-37. However, it has not been reported whether anti-inflammatory medications induce the expression of IL-37. In this work, we uncovered, for the first time, that two main bioactive components, triptolide and triptonide, from the herb Tripterygium wilfordii Hook f. （TwHF）, which possess anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERKI/2 and p38 MAPK inhibitors. Overall, our research demonstrated, for the first time, that anti-inflammatory active components （triptolide and triptonide） upregulated the expression of IL-37 most likely via activation of the ERKI/2 and p38 MAPK pathways. IL-37 is an anti-inflammatory cytokine that was only recently identified, and it is highly expressed in tissues from patients with inflammatory and autoimmune diseases. Inflammatory cytokines and inflammatory stimuli can induce the upregulation of IL-37. However, it has not been reported whether anti-inflammatory medications induce the expression of IL-37. In this work, we uncovered, for the first time, that two main bioactive components, triptolide and triptonide, from the herb Tripterygium wilfordii Hook f. (TwHF), which possess anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERK1/2 and p38 MAPK inhibitors. Overall, our research demonstrated, for the first time, that anti-inflammatory active components (triptolide and triptonide) upregulated the expression of IL-37 most likely via activation of the ERK1/2 and p38 MAPK pathways.Cellular & Molecular Immunology advance online publication, 6 October 2014; doi:10.1038/cmi.2014.92 IL-37 is an anti-inflammatory cytokine that was only recently identified, and it is highly expressed in tissues from patients with inflammatory and autoimmune diseases. Inflammatory cytokines and inflammatory stimuli can induce the upregulation of IL-37. However, it has not been reported whether anti-inflammatory medications induce the expression of IL-37. In this work, we uncovered, for the first time, that two main bioactive components, triptolide and triptonide, from the herb Tripterygium wilfordii Hook f. (TwHF), which possess anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERK1/2 and p38 MAPK inhibitors. Overall, our research demonstrated, for the first time, that anti-inflammatory active components (triptolide and triptonide) upregulated the expression of IL-37 most likely via activation of the ERK1/2 and p38 MAPK pathways. IL-37 is an anti-inflammatory cytokine that was only recently identified, and it is highly expressed in tissues from patients with inflammatory and autoimmune diseases. Inflammatory cytokines and inflammatory stimuli can induce the upregulation of IL-37. However, it has not been reported whether anti-inflammatory medications induce the expression of IL-37. In this work, we uncovered, for the first time, that two main bioactive components, triptolide and triptonide, from the herb Tripterygium wilfordii Hook f. (TwHF), which possess anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERK1/2 and p38 MAPK inhibitors. Overall, our research demonstrated, for the first time, that anti-inflammatory active components (triptolide and triptonide) upregulated the expression of IL-37 most likely via activation of the ERK1/2 and p38 MAPK pathways.Cellular & Molecular Immunology advance online publication, 6 October 2014; doi:10.1038/cmi.2014.92.IL-37 is an anti-inflammatory cytokine that was only recently identified, and it is highly expressed in tissues from patients with inflammatory and autoimmune diseases. Inflammatory cytokines and inflammatory stimuli can induce the upregulation of IL-37. However, it has not been reported whether anti-inflammatory medications induce the expression of IL-37. In this work, we uncovered, for the first time, that two main bioactive components, triptolide and triptonide, from the herb Tripterygium wilfordii Hook f. (TwHF), which possess anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERK1/2 and p38 MAPK inhibitors. Overall, our research demonstrated, for the first time, that anti-inflammatory active components (triptolide and triptonide) upregulated the expression of IL-37 most likely via activation of the ERK1/2 and p38 MAPK pathways.Cellular & Molecular Immunology advance online publication, 6 October 2014; doi:10.1038/cmi.2014.92. |
| Author | Lingge He Zhuangyan Liang Fuqian Zhao Lifei Peng Zhangquan Chen |
| AuthorAffiliation | Key Laboratory for Medical Molecular Diagnostic of Guangdong Province, Guangdong Medical College, Dongguan, China Department of Clinical /m.munolo .gy., Guangdong Medical College, Dongguan, China These authors contributed equally to this work. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25308753$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.jdermsci.2012.11.001 10.1111/j.1365-2125.2012.04221.x 10.1186/1479-5876-12-69 10.1038/ni.1944 10.1371/journal.pone.0008668 10.1111/cei.12061 10.1093/ndt/gfq239 10.3892/ijo.2013.2033 10.1006/meth.2001.1262 |
| ContentType | Journal Article |
| Copyright | Chinese Society of Immunology and The University of Science and Technology 2014 Copyright Nature Publishing Group Jul 2015 Chinese Society of Immunology and The University of Science and Technology 2014. Copyright © 2014 Chinese Society of Immunology and The University of Science and Technology 2014 Chinese Society of Immunology and The University of Science and Technology |
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| DOI | 10.1038/cmi.2014.92 |
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| DocumentTitleAlternate | Modulation of IL-37 expression by triptolide and triptonide in THP-1 cells Triptolide and triptonide upregulate IL-37 expression |
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| Keywords | THP-1 cells IL-37 triptolide triptonide Hook F |
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| Notes | 11-4987/R IL-37 is an anti-inflammatory cytokine that was only recently identified, and it is highly expressed in tissues from patients with inflammatory and autoimmune diseases. Inflammatory cytokines and inflammatory stimuli can induce the upregulation of IL-37. However, it has not been reported whether anti-inflammatory medications induce the expression of IL-37. In this work, we uncovered, for the first time, that two main bioactive components, triptolide and triptonide, from the herb Tripterygium wilfordii Hook f. （TwHF）, which possess anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERKI/2 and p38 MAPK inhibitors. Overall, our research demonstrated, for the first time, that anti-inflammatory active components （triptolide and triptonide） upregulated the expression of IL-37 most likely via activation of the ERKI/2 and p38 MAPK pathways. IL-37; THP-1 cells; Tripterygium wilfordii Hook F.; triptolide; triptonide ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally to this work. |
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| SubjectTerms | Anti-inflammatory agents Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Antibodies Autoimmune diseases Biomedical and Life Sciences Biomedicine Cell Line, Tumor Diterpenes - chemistry Diterpenes - pharmacology Epoxy Compounds - chemistry Epoxy Compounds - pharmacology Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Humans Immunology Interleukin-1 - biosynthesis Interleukin-1 - immunology MAP kinase MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - immunology MAPK信号通路 Medical Microbiology Microbiology Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - immunology Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - immunology Mitogen-Activated Protein Kinase 3 - metabolism p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - immunology p38 Mitogen-Activated Protein Kinases - metabolism Phenanthrenes - chemistry Phenanthrenes - pharmacology Short Communication Tripterygium - chemistry Triptolide Triterpenes - chemistry Triterpenes - pharmacology Vaccine 抗炎活性 活性成分 细胞因子 自身免疫性疾病 药物诱导 雷公藤内酯酮 雷公藤甲素 |
| Title | Modulation of IL-37 expression by triptolide and triptonide in THP-1 cells |
| URI | http://lib.cqvip.com/qk/87787X/201504/665580674.html https://link.springer.com/article/10.1038/cmi.2014.92 https://www.ncbi.nlm.nih.gov/pubmed/25308753 https://www.proquest.com/docview/1785512874 https://www.proquest.com/docview/2760394029 https://www.proquest.com/docview/1694706490 https://www.proquest.com/docview/1790942490 https://pubmed.ncbi.nlm.nih.gov/PMC4496545 |
| Volume | 12 |
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