Modulation of IL-37 expression by triptolide and triptonide in THP-1 cells

• Published in: Cellular & molecular immunology Vol. 12; no. 4; pp. 515 - 518
• Main Authors: He, Lingge, Liang, Zhuangyan, Zhao, Fuqian, Peng, Lifei, Chen, Zhangquan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2015; Nature Publishing Group
• Subjects: Anti-inflammatory agents; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Antibodies; Autoimmune diseases; Biomedical and Life Sciences; Biomedicine; Cell Line, Tumor; Diterpenes - chemistry; Diterpenes - pharmacology; Epoxy Compounds - chemistry; Epoxy Compounds - pharmacology; Gene Expression Regulation - drug effects; Gene Expression Regulation - immunology; Humans; Immunology; Interleukin-1 - biosynthesis; Interleukin-1 - immunology; MAP kinase; MAP Kinase Signaling System - drug effects; MAP Kinase Signaling System - immunology; MAPK信号通路; Medical Microbiology; Microbiology; Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 1 - immunology; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 3 - immunology; Mitogen-Activated Protein Kinase 3 - metabolism; p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases - immunology; p38 Mitogen-Activated Protein Kinases - metabolism; Phenanthrenes - chemistry; Phenanthrenes - pharmacology; Short Communication; Tripterygium - chemistry; Triptolide; Triterpenes - chemistry; Triterpenes - pharmacology; Vaccine; 抗炎活性; 活性成分; 细胞因子; 自身免疫性疾病; 药物诱导; 雷公藤内酯酮; 雷公藤甲素; THP-1 cells; IL-37; triptolide; triptonide; Hook F
• ISSN: 1672-7681; 2042-0226; 2042-0226
• DOI: 10.1038/cmi.2014.92

IL-37 is an anti-inflammatory cytokine that was only recently identified, and it is highly expressed in tissues from patients with inflammatory and autoimmune diseases. Inflammatory cytokines and inflammatory stimuli can induce the upregulation of IL-37. However, it has not been reported whether anti-inflammatory medications induce the expression of IL-37. In this work, we uncovered, for the first time, that two main bioactive components, triptolide and triptonide, from the herb Tripterygium wilfordii Hook f. （TwHF）, which possess anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERKI/2 and p38 MAPK inhibitors. Overall, our research demonstrated, for the first time, that anti-inflammatory active components （triptolide and triptonide） upregulated the expression of IL-37 most likely via activation of the ERKI/2 and p38 MAPK pathways.