The use and efficacy of empirical versus pre-emptive therapy in the management of fungal infections: the HEMA e-Chart Project

• Published in: Haematologica (Roma) Vol. 96; no. 9; pp. 1366 - 1370
• Main Authors: Pagano, L., Caira, M., Nosari, A., Cattaneo, C., Fanci, R., Bonini, A., Vianelli, N., Garzia, M. G., Mancinelli, M., Tosti, M. E., Tumbarello, M., Viale, P., Aversa, F., Rossi, G.
• Format: Journal Article
• Language: English
• Published: Pavia Ferrata Storti Foundation 01.09.2011
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antibiotic Prophylaxis; Antifungal Agents - therapeutic use; Antineoplastic Agents - therapeutic use; Biological and medical sciences; Female; Hematologic and hematopoietic diseases; Hematologic Neoplasms - complications; Hematologic Neoplasms - therapy; Hematopoietic Stem Cell Transplantation - adverse effects; Humans; Kaplan-Meier Estimate; Male; Medical sciences; Middle Aged; Mycoses - drug therapy; Mycoses - etiology; Mycoses - prevention & control; Neutropenia - etiology; Original; Young Adult; Hematology; Mycosis; Treatment efficiency; Malignant hemopathy; empirical antifungal therapy; Infection; Prevention; hematologic malignancies; Antifungal agent; Clinical management; Treatment; pre-emptive antifungal therapy; Comparative study; Cancer

Neutropenic patients with persistent fever despite antibiotic therapy are managed with empirical or pre-emptive antifungal therapy. The aim of the present study was to evaluate the current clinical use and efficacy of these two approaches in patients with high risk hematologic conditions. An electro...