The efficacy and effectiveness of the COVID-19 vaccines in reducing infection, severity, hospitalization, and mortality: a systematic review

With the relatively rapid development of the COVID-19 pandemic, vaccine development has become crucial for limiting disease transmission. The accelerated growth in the approved COVID-19 vaccines has sparked concerns about their efficacies which have been assessed by many studies. This systematic rev...

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Published in	Human vaccines & immunotherapeutics Vol. 18; no. 1; p. 2027160
Main Authors	Mohammed, Ibrahim, Nauman, Areej, Paul, Pradipta, Ganesan, Sanjith, Chen, Kuan-Han, Jalil, Syed Muhammad Saad, Jaouni, Shahd H., Kawas, Hussam, Khan, Wafa A., Vattoth, Ahamed Lazim, Al-Hashimi, Yasmeen Alavi, Fares, Ahmed, Zeghlache, Rached, Zakaria, Dalia
Format	Journal Article
Language	English
Published	United States Taylor & Francis 31.12.2022 Taylor & Francis Group
Subjects	Coronavirus – Review COVID-19 COVID-19 - prevention & control COVID-19 Vaccines effectiveness efficacy Hospitalization Humans Pandemics Review SARS-CoV-2 vaccine COVID-19 effectiveness vaccine efficacy
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Abstract	With the relatively rapid development of the COVID-19 pandemic, vaccine development has become crucial for limiting disease transmission. The accelerated growth in the approved COVID-19 vaccines has sparked concerns about their efficacies which have been assessed by many studies. This systematic review compares the efficacy and effectiveness of seven COVID-19 vaccines. A comprehensive systematic literature search was performed using several databases to identify studies reporting the effectiveness or the efficacy of the vaccines. Only 42 studies met our inclusion criteria, which revealed that the COVID-19 vaccines have successfully reduced the rates of infections, severity, hospitalization, and mortality among the different populations. The full-dose regimen of the Pfizer/BioNTech vaccine is the most effective against infections with the B.1.1.7 and B.1.351 variants. Despite of the high effectiveness of some of the COVID-19 vaccines, more efforts are required to test their effectiveness against the other newly emerging variants.
AbstractList	With the relatively rapid development of the COVID-19 pandemic, vaccine development has become crucial for limiting disease transmission. The accelerated growth in the approved COVID-19 vaccines has sparked concerns about their efficacies which have been assessed by many studies. This systematic review compares the efficacy and effectiveness of seven COVID-19 vaccines. A comprehensive systematic literature search was performed using several databases to identify studies reporting the effectiveness or the efficacy of the vaccines. Only 42 studies met our inclusion criteria, which revealed that the COVID-19 vaccines have successfully reduced the rates of infections, severity, hospitalization, and mortality among the different populations. The full-dose regimen of the Pfizer/BioNTech vaccine is the most effective against infections with the B.1.1.7 and B.1.351 variants. Despite of the high effectiveness of some of the COVID-19 vaccines, more efforts are required to test their effectiveness against the other newly emerging variants.With the relatively rapid development of the COVID-19 pandemic, vaccine development has become crucial for limiting disease transmission. The accelerated growth in the approved COVID-19 vaccines has sparked concerns about their efficacies which have been assessed by many studies. This systematic review compares the efficacy and effectiveness of seven COVID-19 vaccines. A comprehensive systematic literature search was performed using several databases to identify studies reporting the effectiveness or the efficacy of the vaccines. Only 42 studies met our inclusion criteria, which revealed that the COVID-19 vaccines have successfully reduced the rates of infections, severity, hospitalization, and mortality among the different populations. The full-dose regimen of the Pfizer/BioNTech vaccine is the most effective against infections with the B.1.1.7 and B.1.351 variants. Despite of the high effectiveness of some of the COVID-19 vaccines, more efforts are required to test their effectiveness against the other newly emerging variants. With the relatively rapid development of the COVID-19 pandemic, vaccine development has become crucial for limiting disease transmission. The accelerated growth in the approved COVID-19 vaccines has sparked concerns about their efficacies which have been assessed by many studies. This systematic review compares the efficacy and effectiveness of seven COVID-19 vaccines. A comprehensive systematic literature search was performed using several databases to identify studies reporting the effectiveness or the efficacy of the vaccines. Only 42 studies met our inclusion criteria, which revealed that the COVID-19 vaccines have successfully reduced the rates of infections, severity, hospitalization, and mortality among the different populations. The full-dose regimen of the Pfizer/BioNTech vaccine is the most effective against infections with the B.1.1.7 and B.1.351 variants. Despite of the high effectiveness of some of the COVID-19 vaccines, more efforts are required to test their effectiveness against the other newly emerging variants.
Author	Nauman, Areej Fares, Ahmed Chen, Kuan-Han Jaouni, Shahd H. Mohammed, Ibrahim Jalil, Syed Muhammad Saad Khan, Wafa A. Zakaria, Dalia Kawas, Hussam Zeghlache, Rached Vattoth, Ahamed Lazim Al-Hashimi, Yasmeen Alavi Ganesan, Sanjith Paul, Pradipta
Author_xml	– sequence: 1 givenname: Ibrahim surname: Mohammed fullname: Mohammed, Ibrahim organization: Qatar Foundation, Education City – sequence: 2 givenname: Areej surname: Nauman fullname: Nauman, Areej organization: Qatar Foundation, Education City – sequence: 3 givenname: Pradipta orcidid: 0000-0001-6283-1596 surname: Paul fullname: Paul, Pradipta organization: Qatar Foundation, Education City – sequence: 4 givenname: Sanjith surname: Ganesan fullname: Ganesan, Sanjith organization: Qatar Foundation, Education City – sequence: 5 givenname: Kuan-Han surname: Chen fullname: Chen, Kuan-Han organization: Qatar Foundation, Education City – sequence: 6 givenname: Syed Muhammad Saad surname: Jalil fullname: Jalil, Syed Muhammad Saad organization: Qatar Foundation, Education City – sequence: 7 givenname: Shahd H. surname: Jaouni fullname: Jaouni, Shahd H. organization: Qatar Foundation, Education City – sequence: 8 givenname: Hussam surname: Kawas fullname: Kawas, Hussam organization: Qatar Foundation, Education City – sequence: 9 givenname: Wafa A. surname: Khan fullname: Khan, Wafa A. organization: Qatar Foundation, Education City – sequence: 10 givenname: Ahamed Lazim surname: Vattoth fullname: Vattoth, Ahamed Lazim organization: Qatar Foundation, Education City – sequence: 11 givenname: Yasmeen Alavi surname: Al-Hashimi fullname: Al-Hashimi, Yasmeen Alavi organization: Qatar Foundation, Education City – sequence: 12 givenname: Ahmed surname: Fares fullname: Fares, Ahmed organization: Qatar Foundation, Education City – sequence: 13 givenname: Rached orcidid: 0000-0002-8243-7438 surname: Zeghlache fullname: Zeghlache, Rached organization: Qatar Foundation, Education City – sequence: 14 givenname: Dalia orcidid: 0000-0001-9020-0038 surname: Zakaria fullname: Zakaria, Dalia email: dez2003@Qatar-med.cornell.edu organization: Qatar Foundation, Education City
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/35113777$$D View this record in MEDLINE/PubMed
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