Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis

• Published in: Redox report : communications in free radical research Vol. 28; no. 1; p. 2152607
• Main Authors: Dong, Xing-Qiang, Chu, Li-Kai, Cao, Xu, Xiong, Qian-Wei, Mao, Yi-Ming, Chen, Ching-Hsien, Bi, Yun-Li, Liu, Jun, Yan, Xiang-Ming
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 31.12.2023; Taylor & Francis Group
• Subjects: Acute kidney injury; Acute Kidney Injury - chemically induced; Acute Kidney Injury - metabolism; Animals; Apoptosis; Baicalein; Cisplatin; Ferroptosis; Glutathione - metabolism; JAK/STAT3; Kidney - metabolism; Mice; renal tubular; JAK/STAT3; ferroptosis; Acute kidney injury; Baicalein; apoptosis; Glutathione metabolism; Cisplatin; renal tubular

Renal proximal tubular cells are highly vulnerable to different types of assaults during filtration and reabsorption, leading to acute renal dysfunction and eventual chronic kidney diseases (CKD). The chemotherapeutic drug cisplatin elicits cytotoxicity causing renal tubular cell death, but its exec...