Lipoprotein(a) Concentration and Risks of Cardiovascular Disease and Diabetes

• Published in: Journal of the American College of Cardiology Vol. 74; no. 24; pp. 2982 - 2994
• Main Authors: Gudbjartsson, Daniel F., Thorgeirsson, Gudmundur, Sulem, Patrick, Helgadottir, Anna, Gylfason, Arnaldur, Saemundsdottir, Jona, Bjornsson, Eythor, Norddahl, Gudmundur L., Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Eggertsson, Hannes P., Gretarsdottir, Solveig, Thorleifsson, Gudmar, Indridason, Olafur S., Palsson, Runolfur, Jonasson, Fridbert, Jonsdottir, Ingileif, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Olafsson, Isleifur, Danielsen, Ragnar, Matthiasson, Stefan E., Kristmundsdottir, Snaedis, Halldorsson, Bjarni V., Hreidarsson, Astradur B., Valdimarsson, Einar M., Gudnason, Thorarinn, Benediktsson, Rafn, Steinthorsdottir, Valgerdur, Thorsteinsdottir, Unnur, Holm, Hilma, Stefansson, Kari
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.12.2019; Elsevier Limited
• Subjects: Alternative splicing; Aortic valve; Apolipoproteins; Cardiology; Cardiovascular; Cardiovascular disease; Cardiovascular diseases; Case-Control Studies; Cholesterol; Congestive heart failure; Coronary artery; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - genetics; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; DNA Copy Number Variations; genetics; Genomes; Haplotypes; Heart attacks; Homozygotes; Humans; Iceland; Kringles; Life span; Lipoprotein(a) - blood; Lipoprotein(a) - genetics; Lipoproteins; Lp(a); Mendelian randomization; Mendelian Randomization Analysis; Methods; Molecular Weight; Protein Isoforms - blood; Rheumatic heart disease; Risk Factors; Stenosis; Stroke; Thromboembolism; type 2 diabetes; Vascular diseases; Iceland; coronary artery disease; OR; CI; CAD; T2D; Mendelian randomization; Lp(a); HDL; genetics; type 2 diabetes; apo(a); SNP; LDL; HbA1c; KIV-2; hemoglobin A 1c; kringle IV type 2; low density lipoprotein; single nucleotide polymorphism; odds ratio; apolipoprotein(a); HbA 1c; confidence interval; high density lipoprotein; lipoprotein(a)

Lipoprotein(a) [Lp(a)] is a causal risk factor for cardiovascular diseases that has no established therapy. The attribute of Lp(a) that affects cardiovascular risk is not established. Low levels of Lp(a) have been associated with type 2 diabetes (T2D). This study investigated whether cardiovascular...