Inflammatory pathways in alcoholic steatohepatitis

• Published in: Journal of hepatology Vol. 70; no. 2; pp. 249 - 259
• Main Authors: Gao, Bin, Ahmad, Maleeha F., Nagy, Laura E., Tsukamoto, Hidekazu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2019; Elsevier Science Ltd
• Subjects: Alcoholic hepatitis; Animals; Cell interactions; Cell signaling; Chemokines; Cytokines; DAMPS; Dysbacteriosis; Dysbiosis - chemically induced; Dysbiosis - metabolism; Ethanol - pharmacology; Fatty Liver, Alcoholic - metabolism; Gastrointestinal Microbiome - drug effects; Gut barrier; Hepatitis; Hepatitis, Alcoholic - metabolism; Hepatocytes; Hepatocytes - drug effects; Hepatocytes - metabolism; Humans; Immune system; Infiltrating monocytes; Inflammation; Inflammation - chemically induced; Inflammation - metabolism; Inflammation Mediators - metabolism; Intestinal dysbiosis; Intestine; Kupffer cells; Kupffer Cells - drug effects; Kupffer Cells - metabolism; Liver; Macrophages; miRNA; Monocytes; Neutrophils; Neutrophils - drug effects; Neutrophils - metabolism; PAMPs; T-Lymphocytes - drug effects; T-Lymphocytes - metabolism; Therapeutic applications; Intestinal dysbiosis; Infiltrating monocytes; Alcoholic hepatitis; Kupffer cells; Gut barrier; Neutrophils; PAMPs; DAMPS

Inflammatory processes are primary contributors to the development and progression of alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis characterised by non-resolving inflammation. Inflammation in the progression of ASH is a complex response to microbial dysbiosis, loss of barrier int...