A matched cross-sectional study of the association between circulating tissue factor activity, immune activation and advanced liver fibrosis in hepatitis C infection

• Published in: BMC infectious diseases Vol. 15; no. 1; p. 190
• Main Authors: Hodowanec, Aimee C, Lee, Rebecca D, Brady, Kirsten E, Gao, Weihua, Kincaid, Stacey, Plants, Jill, Bahk, Mieoak, Mackman, Nigel, Landay, Alan L, Huhn, Gregory D
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.04.2015; BioMed Central
• Subjects: Adult; Biomarkers - blood; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes - cytology; CD4-Positive T-Lymphocytes - immunology; Coinfection - diagnosis; Complications and side effects; Cross-Sectional Studies; Diagnosis; Female; Fibrosis; Flow Cytometry; Health aspects; Hepatitis C - complications; Hepatitis C - diagnosis; Hepatitis C - immunology; Hepatitis C, Chronic - complications; Hepatitis C, Chronic - diagnosis; Hepatitis C, Chronic - immunology; HIV (Viruses); HIV Infections - complications; HIV Infections - diagnosis; HIV Infections - immunology; Humans; Liver - diagnostic imaging; Liver cirrhosis; Liver Cirrhosis - complications; Liver Cirrhosis - diagnosis; Liver Cirrhosis - pathology; Male; Middle Aged; Pharmaceutical industry; Risk factors; Thromboplastin - analysis; Ultrasonography; United States

Tissue factor (TF) is a protein that mediates the initiation of the coagulation cascade. TF expression is increased in patients with poorly-controlled HIV, and may be associated with increased immune activation that leads to cardiovascular morbidity. The role of TF in immune activation in liver dise...