Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome

• Published in: BMC biology Vol. 13; no. 1; p. 27
• Main Authors: Venkatraman Girija, Umakhanth, Furze, Christopher M, Gingras, Alexandre R, Yoshizaki, Takayuki, Ohtani, Katsuki, Marshall, Jamie E, Wallis, A Katrine, Schwaeble, Wilhelm J, El-Mezgueldi, Mohammed, Mitchell, Daniel A, Moody, Peter C E, Wakamiya, Nobutaka, Wallis, Russell
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.04.2015; BioMed Central
• Subjects: Abnormalities, Multiple - genetics; Analysis; Animals; Calcium - metabolism; Carbohydrates - chemistry; Cattle; Cells; CHO Cells; Collectins - chemistry; Collectins - genetics; Collectins - metabolism; Complement Activation; Cricetinae; Cricetulus; Crystallography, X-Ray; Disaccharides - metabolism; Genetic aspects; Glycoproteins - metabolism; Humans; Kinetics; Ligands; Models, Molecular; Mutant Proteins - metabolism; Mutation - genetics; Physiological aspects; Protein Binding; Protein Biosynthesis; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Syndrome

Collectin-K1 (CL-K1, or CL-11) is a multifunctional Ca(2+)-dependent lectin with roles in innate immunity, apoptosis and embryogenesis. It binds to carbohydrates on pathogens to activate the lectin pathway of complement and together with its associated serine protease MASP-3 serves as a guidance cue...