Patterned progression of bacterial populations in the premature infant gut

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 34; pp. 12522 - 12527
• Main Authors: La Rosa, Patricio S., Warner, Barbara B., Zhou, Yanjiao, Weinstock, George M., Sodergren, Erica, Hall-Moore, Carla M., Stevens, Harold J., Bennett, William E., Shaikh, Nurmohammad, Linneman, Laura A., Hoffmann, Julie A., Hamvas, Aaron, Deych, Elena, Shands, Berkley A., Shannon, William D., Tarr, Phillip I.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 26.08.2014; National Acad Sciences
• Subjects: Age Factors; anaerobes; Antibiotics; Bacteria; bacterial communities; Biological Sciences; Clostridium; Clostridium - genetics; Clostridium - isolation & purification; Cohort Studies; Community development; diet; digestive system; ecological succession; Feces - microbiology; gamma-Proteobacteria; Gammaproteobacteria; Gastrointestinal Tract - microbiology; genes; Genomes; Gestational age; governance; Humans; Infant, Newborn; Infant, Premature; Infants; Inflammatory bowel disease; Intensive Care Units, Neonatal; intestinal microorganisms; Male; microbiome; Microbiota; Microbiota - genetics; Microorganisms; Pediatrics; premature birth; Prospective Studies; Regression analysis; ribosomal RNA; RNA, Bacterial - genetics; RNA, Ribosomal, 16S - genetics; sequence analysis; Taxa; mixed model regression analysis; nonmetric multidimensional scaling; necrotizing enterocolitis; prematurity

In the weeks after birth, the gut acquires a nascent microbiome, and starts its transition to bacterial population equilibrium. This early-in-life microbial population quite likely influences later-inlife host biology. However, we know little about the governance of community development: does the g...