Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

• Published in: Neural regeneration research Vol. 20; no. 4; pp. 990 - 1008
• Main Authors: Zhang, Lan, Wei, Jingge, Liu, Xilei, Li, Dai, Pang, Xiaoqi, Chen, Fanglian, Cao, Hailong, Lei, Ping
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow 01.04.2025; Medknow Publications & Media Pvt. Ltd; Tianjin Geriatrics Institute,Tianjin Medical University General Hospital,Tianjin,China%Department of Gastroenterology and Hepatology,Tianjin Medical University General Hospital,National Key Clinical Specialty,Tianjin Institute of Digestive Diseases,Tianjin Key Laboratory of Digestive Diseases,Tianjin,China%Department of Urology,Tianjin Medical University General Hospital,Tianjin,China%Tianjin Neurological Institution,Tianjin Medical University General Hospital,Tianjin,China; Haihe Laboratory of Cell Ecosystem,Department of Geriatrics,Tianjin Medical University General Hospital,Tianjin,China; Wolters Kluwer Medknow Publications
• Edition: 2
• Subjects: age; Aging; alzheimer’s disease; astrocytes; cognitive decline; dementia; Gut microbiota; Gut-brain axis; Metabolites; microbial metabolites; Microbiota; neuroinflammation; parkinson’s disease; Review; Vagus nerve; microbial metabolites; Parkinson's disease; neuroinflammation; dementia; aging; astrocytes; cognitive decline; Alzheimer's disease; age; gut microbiota; gut-brain axis

With the rapidly aging human population, age-related cognitive decline and dementia are becoming increasingly prevalent worldwide. Aging is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota, microbial metabolites, and the func...