Evaluation of the European tick-borne encephalitis vaccine against Omsk hemorrhagic fever virus

• Published in: Microbiology and immunology Vol. 58; no. 2; p. 112
• Main Authors: Chidumayo, Nozyechi N, Yoshii, Kentaro, Kariwa, Hiroaki
• Format: Journal Article
• Language: English
• Published: Australia 01.02.2014
• Subjects: Animals; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Antigens, Viral - immunology; Cross Reactions - immunology; Encephalitis Viruses, Tick-Borne - immunology; Encephalitis, Tick-Borne - prevention & control; Female; Hemorrhagic Fever, Omsk - mortality; Hemorrhagic Fever, Omsk - prevention & control; Humans; Mice; Neutralization Tests; Vaccination; Viral Vaccines - administration & dosage; Viral Vaccines - immunology; tick-borne encephalitis vaccine; Omsk hemorrhagic fever virus; tick-borne encephalitis virus

This study focused on the antigenic cross-reactivity between tick-borne encephalitis virus (TBEV) and Omsk hemorrhagic fever virus (OHFV) to assess the efficacy of the commercial TBE vaccine against OHFV infection. Neutralization tests performed on sera from OHFV- and TBEV-infected mice showed that...