Regulation of vascular permeability in cancer metastasis

• Published in: Cancer science Vol. 112; no. 8; pp. 2966 - 2974
• Main Authors: Tomita, Takeshi, Kato, Masayoshi, Hiratsuka, Sachie
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.08.2021; John Wiley and Sons Inc
• Subjects: Analysis; Cancer; Cell surface; endothelial cell; Endothelial cells; Endothelium; Extravasation; Fibrin; Fibrinogen; Fibroblasts; Histamine; Kinases; Metastases; Metastasis; Microvasculature; Molecular modelling; Permeability; Phosphorylation; premetastatic soil; Prostate cancer; Proteins; Review; Tumor cells; Tumors; Vascular endothelial growth factor; fibrinogen; pre-metastatic soil; metastasis; endothelial cell; permeability

Enhancement of vascular permeability is indispensable for cancer metastasis. Weakened endothelial barrier function enhances vascular permeability. Circulating tumor cells moving in the microvasculature tend to invade into stromal tissue at the location where vascular permeability is enhanced. Many b...