Physical activity, obesity and sedentary behavior in cancer etiology: epidemiologic evidence and biologic mechanisms

• Published in: Molecular oncology Vol. 15; no. 3; pp. 790 - 800
• Main Authors: Friedenreich, Christine M., Ryder‐Burbidge, Charlotte, McNeil, Jessica
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.03.2021; John Wiley and Sons Inc; Wiley
• Subjects: Amyloid; Animals; Behavior; Body mass index; Body weight gain; Breast cancer; chronic inflammation; Colon; Cytokines; Disease prevention; Energy expenditure; Energy intake; Energy requirements; Epidemiology; Esophagus; Etiology; Exercise; Globulins; Growth factors; hormone; Humans; Incidence; Insulin; Insulin-like growth factors; Lung cancer; Medical research; Metabolism; Neoplasms - epidemiology; Obesity; Obesity - complications; Ovaries; Physical activity; Physical fitness; Prostate; Protective Factors; Reactive oxygen species; Review; Risk Factors; Sedentary Behavior; Sex hormones; Smoking; Tumor necrosis factor; Tumor necrosis factor-TNF; metabolism; sedentary behavior; chronic inflammation; obesity; hormone; physical activity

An estimated 4 in 10 cancers are preventable through modifiable risk factors. This review summarizes the epidemiologic evidence linking physical activity, sedentary behavior, and obesity with cancer risk. We explore the possible biologic mechanisms underpinning the associations between these lifesty...