Clinical CVVH model removes endothelium-derived microparticles from circulation

• Published in: Journal of extracellular vesicles Vol. 3; no. 1; pp. 1 - n/a
• Main Authors: Abdelhafeez, Abdelhafeez H., Jeziorczak, Paul M., Schaid, Terry R., Hoefs, Susan L., Kaul, Sushma, Nanchal, Rahul, Jacobs, Elizabeth R., Densmore, John C.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2014; John Wiley & Sons, Inc; Co-Action Publishing; Wiley
• Subjects: acute lung injury; Animal models; Annexin V; Apoptosis; Cardiovascular disease; Cell activation; Dialysate; dialysis; Disease; Endothelial cells; Endothelium; Enumeration; Flow cytometry; Full text; Hemodialysis; Latex beads; Membrane vesicles; Microparticles; Mortality; Patients; Pediatrics; Plasma; Respiratory distress syndrome; Rodents; Short Communication; Surgery; Umbilical vein; dialysis; endothelium; microparticles; acute lung injury

Endothelium-derived microparticles (EMPs) are submicron vesicles released from the plasma membrane of endothelial cells in response to injury, apoptosis or activation. We have previously demonstrated EMP-induced acute lung injury (ALI) in animal models and endothelial barrier dysfunction in vitro. C...