Proteomic strategies for the discovery of novel diagnostic and therapeutic targets for infectious diseases

• Published in: Pathogens and Disease Vol. 71; no. 2; pp. 177 - 189
• Main Authors: Amaya, Moushimi, Baer, Alan, Voss, Kelsey, Campbell, Catherine, Mueller, Claudius, Bailey, Charles, Kehn Hall, Kylene, Petricoin, Emanuel, Narayanan, Aarthi
• Format: Journal Article Book Review
• Language: English
• Published: United States Blackwell Publishing Ltd 01.07.2014; Oxford University Press; John Wiley and Sons Inc
• Subjects: Biomarkers - analysis; Diagnostic Tests, Routine - methods; Drug Discovery - methods; Host-Pathogen Interactions; Humans; Infectious diseases; Mass spectrometry; Mass Spectrometry - methods; Medical research; MiniReview; MiniReviews; Protein Array Analysis - methods; Proteins; protein–protein interactions; Proteomics - methods; reverse‐phase protein microarray; Virus Diseases - diagnosis; Virus Diseases - drug therapy; protein–protein interactions; mass spectrometry; reverse phase protein microarray; reverse-phase protein microarray; protein-protein interactions

Abstract Viruses have developed numerous and elegant strategies to manipulate the host cell machinery to establish a productive infectious cycle. The interaction of viral proteins with host proteins plays an important role in infection and pathogenesis, often bypassing traditional host defenses such...