西安及周边地区HCV基因型构成分析
HCV可分为6个主要类型（1、2、3、4、5和6型）,每个类型又可以继续分为多种亚型[1]。HCV基因组高突变率的特点极大的阻碍了疫苗及治疗性抗体的研发。中国现行HCV标准治疗方案主要依赖于聚乙二醇干扰素（PEG-IFN）联合利巴韦林[2],但随着新的直接抗病毒药物（direct acting antiviral agents,DAA）的研发及临床运用,病毒清除率得到极大的提高,HCV NS5蛋白酶抑制剂——索非布韦（sofosbuvir）能够有效抑制多种类型病毒复制[3]....
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| Published in | 临床肝胆病杂志 Vol. 32; no. 6; pp. 1165 - 1166 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
第四军医大学唐都医院传染科,西安,710038
2016
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 |
| DOI | 10.3969/j.issn.1001-5256.2016.06.030 |
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| Abstract | HCV可分为6个主要类型（1、2、3、4、5和6型）,每个类型又可以继续分为多种亚型[1]。HCV基因组高突变率的特点极大的阻碍了疫苗及治疗性抗体的研发。中国现行HCV标准治疗方案主要依赖于聚乙二醇干扰素（PEG-IFN）联合利巴韦林[2],但随着新的直接抗病毒药物（direct acting antiviral agents,DAA）的研发及临床运用,病毒清除率得到极大的提高,HCV NS5蛋白酶抑制剂——索非布韦（sofosbuvir）能够有效抑制多种类型病毒复制[3]. |
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| AbstractList | HCV可分为6个主要类型（1、2、3、4、5和6型）,每个类型又可以继续分为多种亚型[1]。HCV基因组高突变率的特点极大的阻碍了疫苗及治疗性抗体的研发。中国现行HCV标准治疗方案主要依赖于聚乙二醇干扰素（PEG-IFN）联合利巴韦林[2],但随着新的直接抗病毒药物（direct acting antiviral agents,DAA）的研发及临床运用,病毒清除率得到极大的提高,HCV NS5蛋白酶抑制剂——索非布韦（sofosbuvir）能够有效抑制多种类型病毒复制[3]. R512.63 |
| Author | 叶传涛 赵洁茹 郑煦阳 边培育 贾战生 |
| AuthorAffiliation | 第四军医大学唐都医院传染科,西安710038 |
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| DocumentTitleAlternate | HCV genotype distribution in Xi＇an and surroundings areas |
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| Keywords | 基因型 hepacivirus age distribution 性别分布 肝炎病毒属 sex distribution 年龄分布 genotype |
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| Notes | hepacivirus ; genotype ; age distribution ; sex distribution YE Chuantao, ZHAO Jieru, ZHENG Xuyang, et al. （Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical Universi- ty, Xi＇an 710038, China） 22-1108/R |
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| PublicationTitleAlternate | Chinese Journal of Clinical Hepatology |
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| Snippet | HCV可分为6个主要类型（1、2、3、4、5和6型）,每个类型又可以继续分为多种亚型[1]。HCV基因组高突变率的特点极大的阻碍了疫苗及治疗性抗体的研发。中国现行HCV标准治疗方案主要依赖于聚乙二醇干扰素（PEG-IFN）联合利巴韦林[2],但随着新的直接抗病毒药物（direct acting antiviral... R512.63 |
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| SubjectTerms | 基因型 年龄分布 性别分布 肝炎病毒属 |
| Title | 西安及周边地区HCV基因型构成分析 |
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