血清C反应蛋白、脂肪酶、白细胞介素1β和细胞间黏附分子1联合检测在急性胰腺炎诊断中的应用价值
目的通过动态检测急性胰腺炎（AP）患者外周血清C反应蛋白（CRP）、脂肪酶（LPS）、白细胞介素（IL）1β和细胞间黏附分子（ICAM）1的水平及变化,评价多种指标联合检测在AP临床诊断中的价值。方法收集2010年1月-2012年12月在中国医科大学附属第四医院进行治疗的AP患者86例,其中重症急性胰腺炎（SAP）患者39例,轻症急性胰腺炎（MAP）患者47例。于入院第1、3、5、7天分别采集患者血清,另选取12例同期健康体检者作为对照。采用ELISA法检测血清中CRP、IL-1β和ICAM-1水平,干片速率法测定血清LPS的浓度。计量资料组间比较采用t检验,计数资料组间比较采用χ2检验。结果...
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| Published in | 临床肝胆病杂志 Vol. 32; no. 1; pp. 131 - 134 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
中国医科大学附属第四医院 消化科,沈阳,110032
2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 |
| DOI | 10.3969/j.issn.1001-5256.2016.01.025 |
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| Abstract | 目的通过动态检测急性胰腺炎（AP）患者外周血清C反应蛋白（CRP）、脂肪酶（LPS）、白细胞介素（IL）1β和细胞间黏附分子（ICAM）1的水平及变化,评价多种指标联合检测在AP临床诊断中的价值。方法收集2010年1月-2012年12月在中国医科大学附属第四医院进行治疗的AP患者86例,其中重症急性胰腺炎（SAP）患者39例,轻症急性胰腺炎（MAP）患者47例。于入院第1、3、5、7天分别采集患者血清,另选取12例同期健康体检者作为对照。采用ELISA法检测血清中CRP、IL-1β和ICAM-1水平,干片速率法测定血清LPS的浓度。计量资料组间比较采用t检验,计数资料组间比较采用χ2检验。结果 MAP组患者入院第1天的CRP、IL-1β和LPS水平明显高于对照组,差异均有统计学意义（t值分别为-74.126、-60.135、-364.153,P值均〈0.001）;SAP组患者入院第1天的CRP、ICAM-1、IL-1β、LPS水平均明显高于对照组,差异亦有统计学意义（t值分别为-121.355、-25.728、-89.422、-415.840,P值均〈0.001）;各检测指标浓度的峰值出现在入院第1天或第3天,且随着治疗时间的延长,浓度呈进行性下降;与MAP患者相比,SAP患者血清中CRP、LPS、IL-1β和ICAM-1水平均较高,差异均有统计学意义（P值均〈0.05）。结论联合检测患者血清CRP、LPS、IL-1β和ICAM-1水平对于AP严重程度的早期判断具有一定的临床参考价值。 |
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| AbstractList | R576; 目的：通过动态检测急性胰腺炎（AP）患者外周血清C反应蛋白（CRP）、脂肪酶（LPS）、白细胞介素（IL）1β和细胞间黏附分子（ICAM）1的水平及变化，评价多种指标联合检测在AP临床诊断中的价值。方法收集2010年1月－2012年12月在中国医科大学附属第四医院进行治疗的AP患者86例，其中重症急性胰腺炎（SAP）患者39例，轻症急性胰腺炎（MAP）患者47例。于入院第1、3、5、7天分别采集患者血清，另选取12例同期健康体检者作为对照。采用ELISA法检测血清中CRP、IL－1β和ICAM－1水平，干片速率法测定血清LPS的浓度。计量资料组间比较采用t检验，计数资料组间比较采用χ2检验。结果 MAP组患者入院第1天的CRP、IL－1β和LPS水平明显高于对照组，差异均有统计学意义（t值分别为－74．126、－60．135、－364．153，P值均＜0．001）；SAP组患者入院第1天的CRP、ICAM－1、IL－1β、LPS水平均明显高于对照组，差异亦有统计学意义（t值分别为－121．355、－25．728、－89．422、－415．840，P值均＜0．001）；各检测指标浓度的峰值出现在入院第1天或第3天，且随着治疗时间的延长，浓度呈进行性下降；与MAP患者相比，SAP患者血清中CRP、LPS、IL－1β和ICAM－1水平均较高，差异均有统计学意义（P值均＜0．05）。结论联合检测患者血清CRP、LPS、IL－1β和ICAM－1水平对于AP严重程度的早期判断具有一定的临床参考价值。 目的通过动态检测急性胰腺炎（AP）患者外周血清C反应蛋白（CRP）、脂肪酶（LPS）、白细胞介素（IL）1β和细胞间黏附分子（ICAM）1的水平及变化,评价多种指标联合检测在AP临床诊断中的价值。方法收集2010年1月-2012年12月在中国医科大学附属第四医院进行治疗的AP患者86例,其中重症急性胰腺炎（SAP）患者39例,轻症急性胰腺炎（MAP）患者47例。于入院第1、3、5、7天分别采集患者血清,另选取12例同期健康体检者作为对照。采用ELISA法检测血清中CRP、IL-1β和ICAM-1水平,干片速率法测定血清LPS的浓度。计量资料组间比较采用t检验,计数资料组间比较采用χ2检验。结果 MAP组患者入院第1天的CRP、IL-1β和LPS水平明显高于对照组,差异均有统计学意义（t值分别为-74.126、-60.135、-364.153,P值均〈0.001）;SAP组患者入院第1天的CRP、ICAM-1、IL-1β、LPS水平均明显高于对照组,差异亦有统计学意义（t值分别为-121.355、-25.728、-89.422、-415.840,P值均〈0.001）;各检测指标浓度的峰值出现在入院第1天或第3天,且随着治疗时间的延长,浓度呈进行性下降;与MAP患者相比,SAP患者血清中CRP、LPS、IL-1β和ICAM-1水平均较高,差异均有统计学意义（P值均〈0.05）。结论联合检测患者血清CRP、LPS、IL-1β和ICAM-1水平对于AP严重程度的早期判断具有一定的临床参考价值。 |
| Abstract_FL | Objective Toevaluatethevalueofcombineddeterminationofvariousindicesintheclinicaldiagnosisofacutepancreatitis (AP)through dynamic measurements of the levels of peripheral serum C-reactive protein (CRP),lipase (LPS),interleukin-1β(IL-1β),andintercellularadhesionmolecule1(ICAM-1),aswellaschangesintheirlevels,inpatientswithAP.Methods Atotalof86 patients with AP who were treated in Fourth Affiliated Hospital of China Medical University from January 2010 to December 2012 were select-ed,among whom there were 39 patients with severe acute pancreatitis (SAP)and 47 patients with mild acute pancreatitis (MAP).Serum sam-ples were collected from these patients on days 1,3,5,and 7 of admission.Twelve healthy subjects were selected as controls.Enzyme-linked immunosorbent assay was applied to measure the levels of CRP,IL-1β,and ICAM-1 ,and the dry slides method was applied to measure the concentration of serum LPS.The t test and χ2 test were applied for comparison of continuous data and categorical data between groups, respectively.Results Onday1ofadmission,thepatientsinMAPgrouphadsignificantlyhigherlevelsofCRP,IL-1β,andLPSthan those in control group (t=-74.126,-60.135,and -364.153,respectively;all P<0.001);on day 1 of admission,the patients in SAP group had significantly higher levels of CRP,ICAM-1,IL-1β,and LPS than those in control group (t=-121.355,-25.728,-89.422,and -415.840,respectively;all P<0.001).The peak concentration of each index appeared on day 1 or 3 of admission,and decreased progressively in the course of therapy.The patients in SAP group had significantly higher levels of serum CRP,LPS,IL-1β,and ICAM-1thanthoseinMAPgroup(allP<0.05).Conclusion CombineddeterminationofserumCRP,LPS,IL-1β,andICAM-1 levels has a certain clinical value in early identification of severity of AP. |
| Author | 矫树华 刘鹏亮 温艳惠 |
| AuthorAffiliation | 中国医科大学附属第四医院消化科,沈阳110032 |
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| Author_FL | JIAO Shuhua WEN Yanhui LIU Pengliang |
| Author_FL_xml | – sequence: 1 fullname: JIAO Shuhua – sequence: 2 fullname: LIU Pengliang – sequence: 3 fullname: WEN Yanhui |
| Author_xml | – sequence: 1 fullname: 矫树华 刘鹏亮 温艳惠 |
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| DocumentTitleAlternate | Combined determination of serum C - reactive protein, lipase, interleukin - 1 β, and intercellular adhesion molecule 1 in early identification of severity of acute pancreatitis |
| DocumentTitle_FL | Combined determination of serum C-reactive protein,lipase,interleukin-1β,and intercellular adhesion molecule 1 in early identification of severity of acute pancreatitis |
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| Keywords | 胰腺炎 诊断 白细胞介素1β 胞间黏附分子1 C-reactive protein interleukin-1 beta lipase diagnosis 脂肪酶 pancreatitis C反应蛋白质 intercellular adhesion molecule-1 |
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| Notes | JIAO Shuhna, LIU Pengliang, WEN Yanhui. （ Department of Gastroenterology, Fourth Affiliated Hospital of China Medical University, Shen- yang 110032, China） panereatitis; C- reactive protein; lipase; interleukin- l beta; intercellular adhesion molecule- 1; diagnosis Objective To evaluate the value of combined determination of various indices in the clinical diagnosis of acute pancreatitis （AP） through dynamic measurements of the levels of peripheral serum C -reactive protein （CRP） , lipase （LPS） , interleukin- 1β （IL- 113）, and intercellular adhesion molecule 1 （ ICAM - 1 ）, as well as changes in their levels, in patients with AP. Methods A total of 86 patients with AP who were treated in Fourth Affiliated Hospital of China Medical University from January 2010 to December 2012 were selected, among whom there were 39 patients with severe acute panereatitis （SAP） and 47 patients with mild acute panereatitis （MAP）. Serum sam- ples were collected from these patients on days 1,3,5, and 7 of admission. Twelve healthy |
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| PublicationTitle | 临床肝胆病杂志 |
| PublicationTitleAlternate | Chinese Journal of Clinical Hepatology |
| PublicationYear | 2016 |
| Publisher | 中国医科大学附属第四医院 消化科,沈阳,110032 |
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| SubjectTerms | C反应蛋白质 白细胞介素1β 胞间黏附分子1 胰腺炎 脂肪酶 诊断 |
| Title | 血清C反应蛋白、脂肪酶、白细胞介素1β和细胞间黏附分子1联合检测在急性胰腺炎诊断中的应用价值 |
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