PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis - Hou, Junwei; Zhao, Rongce; Xia, Weiya; Chang, Chiung-Wen; You, Yun; Hsu, Jung-Mao; Nie, Lei; Chen, Yeh; Wang, Yu-Chuan; Liu, Chunxiao; Wang, Wei-Jan; Wu, Yun; et al. (Nature cell biology, 2020)
Keywords: 13/1; 13/106; 13/51; 631/67; 631/80/82; 64/60; Animals; Antibiotics; Apoptosis; B7-H1 Antigen - genetics; B7-H1 Antigen - metabolism; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Biomedical and Life Sciences; Breast cancer; Cancer; Cancer cells; Cancer Research; Caspase-8; Cell Biology; Cell membranes; Cell Proliferation; Cellular proteins; Chemotherapy; Developmental Biology; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Female; Gene expression; Gene Expression Regulation, Neoplastic; Genetic aspects; Health aspects; Humans; Hypoxia; Hypoxia - physiopathology; Immune checkpoint; Immunosuppressive agents; Inflammasomes; Life Sciences; Macrophages; Mice; Mice, Inbred BALB C; Mice, Nude; Necrosis; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Nuclear transport; Nuclei (cytology); PD-L1 protein; Pyroptosis; Stat3 protein; Stem Cells; Switches; Transcription; Translocation; Tumor Cells, Cultured; Tumor necrosis factor-α; Tumor-Associated Macrophages; Tumors; Xenograft Model Antitumor Assays; United States