The curative effect of fucoidan on visceral leishmaniasis is mediated by activation of MAP kinases through specific protein kinase C isoforms

• Published in: Cellular & molecular immunology Vol. 11; no. 3; pp. 263 - 274
• Main Authors: Sharma, Gunjan, Kar, Susanta, Basu Ball, Writoban, Ghosh, Kuntal, Das, Pijush K
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2014; Nature Publishing Group
• Subjects: Animals; Antibodies; Antibodies, Monoclonal - pharmacology; Antibodies, Monoclonal - therapeutic use; Antimony; Biomedicine; Cell Line; C亚型; Electrophoretic mobility; Enzymatic activity; Enzyme Activation - drug effects; Extracellular signal-regulated kinase; Fucoidan; Immune clearance; Immune response; Immunity - drug effects; Immunoblotting; Immunology; Inflammation Mediators - metabolism; Interleukin 12; Isoenzymes - metabolism; Isoforms; Kinases; Leishmania; Leishmania donovani - drug effects; Leishmaniasis, Visceral - drug therapy; Leishmaniasis, Visceral - enzymology; Leishmaniasis, Visceral - immunology; Leishmaniasis, Visceral - parasitology; Macrophages; MAP kinase; MAP Kinase Signaling System - drug effects; MAP激酶; Medical Microbiology; Mice, Inbred BALB C; Microbiology; Mitogen-Activated Protein Kinases - metabolism; NF-kappa B - metabolism; NF-κB protein; Nitric oxide; Nitric Oxide Synthase Type II - metabolism; Nitric-oxide synthase; Parasitic diseases; Polysaccharides - pharmacology; Polysaccharides - therapeutic use; Protein kinase C; Protein Kinase C - metabolism; Proteins; research-article; Thiazines - pharmacology; Transcription Factor AP-1 - metabolism; Tumor necrosis factor-α; Vaccine; Visceral leishmaniasis; Western blotting; 介导; 促分裂原活化蛋白激酶; 疗效; 蛋白激酶C; 褐藻多糖硫酸酯; 诱导型一氧化氮合酶; NF-κB; PKC; MAPK; fucoidan; visceral leishmaniasis
• ISSN: 1672-7681; 2042-0226; 2042-0226
• DOI: 10.1038/cmi.2013.68

Fucoidan can cure both antimony-sensitive and antimony-resistant visceral leishmaniasis through immune activation. However, the signaling events underlying this cellular response remain uncharacterized. The present study reveals that fucoidan induces activation of p38 and ERKI/2 and NF-κB DNA bindin...