Ideal Duration of Pretreatment Using a Gelatin Hydrogel Nonwoven Fabric Prior to Subcutaneous Islet Transplantation

• Published in: Cell transplantation Vol. 32; p. 9636897231186063
• Main Authors: Saito, Ryusuke, Inagaki, Akiko, Nakamura, Yasuhiro, Imura, Takehiro, Kanai, Norifumi, Mitsugashira, Hiroaki, Endo, Yukiko, Katano, Takumi, Suzuki, Shoki, Tokodai, Kazuaki, Kamei, Takashi, Unno, Michiaki, Watanabe, Kimiko, Tabata, Yasuhiko, Goto, Masafumi
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2023; Sage Publications Ltd; SAGE Publishing
• Subjects: Blood glucose; Collagen (type III); Collagen (type IV); Colony-stimulating factor; Diabetes; Diabetes mellitus; Extracellular matrix; Gelatin; Gene expression; Glucose; Glucose tolerance; Granulocyte colony-stimulating factor; Hydrogels; Immunohistochemistry; Immunological tolerance; Inflammation; Interferon; Islet cells; Laminin; Leukocytes (granulocytic); Nonwoven fabrics; Original; Pancreas; Pancreatic islet transplantation; Silicones; Streptozocin; Syngeneic grafts; Von Willebrand factor; Xenografts; subcutaneous; islet transplantation; extracellular matrix; gelatin hydrogel nonwoven fabrics; neovascularization

Subcutaneous islet transplantation is a promising treatment for severe diabetes; however, poor engraftment hinders its prevalence. We previously revealed that a gelatin hydrogel nonwoven fabric (GHNF) markedly improved subcutaneous islet engraftment in comparison with intraportal islet transplantati...