Influence of Simvastatin-Loaded Implants on Osseointegration in an Ovariectomized Animal Model

• Published in: BioMed research international Vol. 2015; no. 2015; pp. 1 - 7
• Main Authors: Liu, Li, He, Fuming, Zhao, Shifang, Fang, Wen, Yang, Guoli
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2015; Hindawi Limited
• Subjects: Animals; Biocompatibility; Biomedical materials; Bone density; Bones; Chemical bonds; Coated Materials, Biocompatible - pharmacology; Coatings; Durapatite - pharmacology; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Implants, Experimental; Kinases; Osseointegration - drug effects; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Simvastatin - pharmacology; Surgical implants

The success of bone implants in the presence of osteoporosis is limited by lack of osseointegration between the implant and the natural bone. This study applied an electrochemical process to deposit simvastatin-nanohydroxyapatite (HA) coatings on porous implant surfaces and investigated the effects...