Protection of brain and pancreas from high-fat diet: Effects of catechin and caffeine

• Published in: Physiology & behavior Vol. 96; no. 2; pp. 262 - 269
• Main Authors: Unno, Keiko, Yamamoto, Hiroyuki, Maeda, Ken-ichi, Takabayashi, Fumiyo, Yoshida, Hirotoshi, Kikunaga, Naomi, Takamori, Nina, Asahina, Shunsuke, Iguchi, Kazuaki, Sayama, Kazutoshi, Hoshino, Minoru
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 16.02.2009; Elsevier
• Subjects: Aging - drug effects; Aging - metabolism; Aging - pathology; Animals; Behavioral psychophysiology; Biological and medical sciences; Body Weight - drug effects; Brain - drug effects; Caffeine; Caffeine - pharmacology; Catechin - analogs & derivatives; Catechin - chemistry; Catechin - pharmacology; Central Nervous System Stimulants - pharmacology; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - metabolism; Dietary Fats - adverse effects; Eating - drug effects; Female; Fundamental and applied biological sciences. Psychology; Glucose Tolerance Test; Green tea catechin; High-fat diet; Insulin; Lipid Metabolism - drug effects; Maze Learning - drug effects; Medical sciences; Metabolic diseases; Mice; Mice, Mutant Strains; Neuropharmacology; Obesity; Pancreas - drug effects; Pharmacology. Drug treatments; Psychiatry; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopharmacology; SAMP10; Sesquiterpenes - metabolism; Synaptophysin - metabolism; Time Factors; Working memory; EGC; Obesity; Catechin; SDS; dG; EGCG; Green tea catechin; ECG; SAMP10; Insulin; 8-oxodG; DMEM; SE; GT-catechin; High-fat diet; CE-2; Working memory; Caffeine; Cat + Caf; high-fat diet containing 0.05% caffeine; a mouse strain with accelerated senescence; high-fat diet containing both 0.3% GT-catechin and 0.05% caffeine; high-fat diet containing 0.3% GT-catechin; sodium dodecyl sulfate; deoxyguanosine; (−)-epicatechin gallate; 8-oxodeoxyguanosine; standard error; green tea catechins; a high fat diet consisting of 20% soybean oil and 80% normal diet; (−)-epigallocatechin gallate; (−)-epigallocatechin; Dulbecco's modified eagle medium; Pancreatic hormone; CNS stimulant; Psychotropic; Central nervous system; Nutrition disorder; Feeding; Encephalon; Respiratory analeptic; Diet; Fat; Xanthine derivatives; Pancreas; Protection; Green tea; Nutritional status

To investigate the effect of a high-fat diet on brain and pancreas functions, we used SAMP10 mice that have characteristics of brain atrophy and cognitive dysfunction with aging. Simultaneously, we investigated the effect of green tea catechin consumption on high-fat diet feeding, because green tea...