Polypharmacology: drug discovery for the future

In recent years, even with remarkable scientific advancements and a significant increase of global research and development spending, drugs are frequently withdrawn from markets. This is primarily due to their side effects or toxicities. Drug molecules often interact with multiple targets, coined as...

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Bibliographic Details
Published inExpert review of clinical pharmacology Vol. 6; no. 1; pp. 41 - 47
Main Authors Reddy, A Srinivas, Zhang, Shuxing
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 01.01.2013
Taylor & Francis
Expert Reviews Ltd
Subjects
Cancer
Care and treatment
Computational Biology
Databases, Pharmaceutical
Drug Discovery - methods
Drug Discovery - standards
Drug Interactions
drug repurposing
Drug-Related Side Effects and Adverse Reactions
drug-target network
Drugs
Humans
Models, Biological
multitargeting design
off-target
polypharmacology
Polypharmacy
side effects
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Summary:In recent years, even with remarkable scientific advancements and a significant increase of global research and development spending, drugs are frequently withdrawn from markets. This is primarily due to their side effects or toxicities. Drug molecules often interact with multiple targets, coined as polypharmacology, and the unintended drug-target interactions could cause side effects. Polypharmacology remains one of the major challenges in drug development, and it opens novel avenues to rationally design the next generation of more effective, but less toxic, therapeutic agents. This review outlines the latest progress and challenges in polypharmacology studies.
ISSN:1751-2433
1751-2441
DOI:10.1586/ecp.12.74