Diagnostic power of default mode network resting state fMRI in the detection of Alzheimer's disease

• Published in: Neurobiology of aging Vol. 33; no. 3; pp. 466 - 478
• Main Authors: Koch, Walter, Teipel, Stephan, Mueller, Sophia, Benninghoff, Jens, Wagner, Maxmilian, Bokde, Arun L.W., Hampel, Harald, Coates, Ute, Reiser, Maximilian, Meindl, Thomas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2012
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnosis; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Alzheimer's disease; Cerebral Cortex - pathology; Cerebral Cortex - physiopathology; Default mode network; Female; fMRI; Humans; Independent component analysis; Internal Medicine; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - standards; Male; Middle Aged; Nerve Net - pathology; Neurology; Resting Phase, Cell Cycle - physiology; fMRI; Default mode network; Alzheimer's disease; Independent component analysis

Functional magnetic resonance imaging (fMRI) of default mode network (DMN) brain activity during resting is recently gaining attention as a potential noninvasive biomarker to diagnose incipient Alzheimer's disease. The aim of this study was to determine which method of data processing provides...