The immune cell landscape in kidneys of patients with lupus nephritis

• Published in: Nature immunology Vol. 20; no. 7; pp. 902 - 914
• Main Authors: Arazi, Arnon, Rao, Deepak A., Berthier, Celine C., Davidson, Anne, Liu, Yanyan, Hoover, Paul J., Chicoine, Adam, Eisenhaure, Thomas M., Jonsson, A. Helena, Li, Shuqiang, Lieb, David J., Zhang, Fan, Slowikowski, Kamil, Browne, Edward P., Noma, Akiko, Sutherby, Danielle, Steelman, Scott, Smilek, Dawn E., Tosta, Patti, Apruzzese, William, Massarotti, Elena, Dall’Era, Maria, Park, Meyeon, Kamen, Diane L., Furie, Richard A., Payan-Schober, Fernanda, Pendergraft, William F., McInnis, Elizabeth A., Buyon, Jill P., Petri, Michelle A., Putterman, Chaim, Kalunian, Kenneth C., Woodle, E. Steve, Lederer, James A., Hildeman, David A., Nusbaum, Chad, Raychaudhuri, Soumya, Kretzler, Matthias, Anolik, Jennifer H., Brenner, Michael B., Wofsy, David, Hacohen, Nir, Diamond, Betty
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2019; Nature Publishing Group
• Subjects: 631/1647/514/1949; 631/250/256; 631/250/38; 692/699/249/1313; Age; Analysis; Autoimmune diseases; Biomarkers; Biomedical and Life Sciences; Biomedicine; Biopsy; Care and treatment; Cell activation; Chemokine receptors; Cluster Analysis; Complications and side effects; Computational Biology - methods; CX3CR1 protein; CXCR4 protein; Epithelial Cells - metabolism; Flow Cytometry; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Health aspects; Humans; Immunohistochemistry; Immunology; Immunophenotyping; Infectious Diseases; Inflammation; Interferon; Interferons - metabolism; Kidney - immunology; Kidney - metabolism; Kidney - pathology; Kidneys; Leukocytes; Leukocytes - immunology; Leukocytes - metabolism; Lupus; Lupus nephritis; Lupus Nephritis - genetics; Lupus Nephritis - immunology; Lupus Nephritis - metabolism; Lupus Nephritis - pathology; Lymphocytes - immunology; Lymphocytes - metabolism; Lymphocytes B; Lymphocytes T; Molecular Sequence Annotation; Monocytes; Myeloid cells; Myeloid Cells - immunology; Myeloid Cells - metabolism; Natural killer cells; Nephritis; Resource; Ribonucleic acid; Risk factors; RNA; Single-Cell Analysis; Systemic lupus erythematosus; Transcription; Transcriptome; Urine

Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from healthy control subjects using single-cell RNA sequencing. Ou...