Positive selection and evolution of dengue type-3 virus in the Indian subcontinent

• Published in: Journal of vector borne diseases Vol. 50; no. 3; pp. 188 - 196
• Main Authors: Bedi, Sukhmani K, Prasad, Apar, Mathur, Krishanu, Bhatnagar, Sonika
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.09.2013; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Amino Acid Sequence; Amino Acid Substitution; Base Sequence; Bayes Theorem; C-prM; DEN-3; E-NS1; genotype-III; maximum likelihood tree; NS1; phylogenetic analysis; positive selection; predicting evolution; T-cell epitope; Causes of; Dengue; Dengue - epidemiology; Dengue - virology; Dengue Virus - classification; Dengue Virus - genetics; Dengue Virus - isolation & purification; Deoxyribonucleic acid; DNA; Evolution & development; Evolution, Molecular; Genetic aspects; Genetic Variation; Genotype; Genotype & phenotype; Humans; India - epidemiology; Molecular Sequence Data; Monte Carlo Method; Mutation; Natural selection; Phylogenetics; Phylogeny; Population Dynamics; Proteins; RNA, Viral - blood; Selection, Genetic; Sequence Analysis, DNA; Studies; Trees; Viral infections; Viral Proteins - genetics; India; Sri Lanka

Dengue virus infection has recently taken endemic proportions in India with dengu type-3 (DEN-3) as a predominant serotype. In this study, we carried out the selection pressure analysis of three critical immunogenic regions of DEN-3. Phylogenetic analysis was then carried out on the positively selec...