Potential of Adult Endogenous Neural Stem/Progenitor Cells in the Spinal Cord to Contribute to Remyelination in Experimental Autoimmune Encephalomyelitis

• Published in: Cells (Basel, Switzerland) Vol. 8; no. 9; p. 1025
• Main Authors: Maeda, Yuki, Nakagomi, Nami, Nakano-Doi, Akiko, Ishikawa, Hiroto, Tatsumi, Yoshiki, Bando, Yoshio, Yoshikawa, Hiroo, Matsuyama, Tomohiro, Gomi, Fumi, Nakagomi, Takayuki
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.09.2019; MDPI
• Subjects: Animal models; Animals; Antibodies; Astrocytes; Astrocytes - cytology; Astrocytes - metabolism; Cell Lineage; Cells, Cultured; Central nervous system; Demyelination; Encephalomyelitis; Encephalomyelitis, Autoimmune, Experimental - metabolism; Encephalomyelitis, Autoimmune, Experimental - pathology; Experimental allergic encephalomyelitis; experimental autoimmune encephalomyelitis; Female; Glycoproteins; Growth factors; Immunohistochemistry; Inflammation; Laboratories; Mice; Mice, Inbred C57BL; Microscopy; Multiple sclerosis; Myelin; Myelin Sheath - metabolism; Myelination; Nestin; Nestin - genetics; Nestin - metabolism; Neural stem cells; Neural Stem Cells - cytology; Neural Stem Cells - metabolism; neural stem/progenitor cells; Neurogenesis; Oligodendrocyte-myelin glycoprotein; Oligodendrocytes; Oligodendroglia - cytology; Oligodendroglia - metabolism; Paralysis; Progenitor cells; Proteins; remyelination; Spinal cord; Spinal Cord - cytology; Spinal Cord - metabolism; Spinal Cord - pathology; Stem cells; Yellow fluorescent protein; Canada; United States > US; Japan; Nestin; experimental autoimmune encephalomyelitis; spinal cord; multiple sclerosis; neural stem/progenitor cells; remyelination

Demyelination and remyelination play pivotal roles in the pathological process of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), a well-established animal model of MS. Although increasing evidence shows that various stimuli can promote the activation/induction of endoge...