PTEN Interacts with Histone H1 and Controls Chromatin Condensation

• Published in: Cell reports (Cambridge) Vol. 8; no. 6; pp. 2003 - 2014
• Main Authors: Chen, Zhu Hong, Zhu, Minglu, Yang, Jingyi, Liang, Hui, He, Jinxue, He, Shiming, Wang, Pan, Kang, Xi, McNutt, Michael A., Yin, Yuxin, Shen, Wen H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.09.2014; Elsevier
• Subjects: Acetylation; Animals; Cell Line; Chromatin - metabolism; Chromosomal Proteins, Non-Histone - metabolism; Gene Expression Profiling; Histones - chemistry; Histones - genetics; Histones - metabolism; Mice; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; PTEN Phosphohydrolase - deficiency; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism

Chromatin organization and dynamics are integral to global gene transcription. Histone modification influences chromatin status and gene expression. PTEN plays multiple roles in tumor suppression, development, and metabolism. Here, we report on the interplay of PTEN, histone H1, and chromatin. We sh...