Can tissue engineering concepts advance tumor biology research?

• Published in: Trends in biotechnology (Regular ed.) Vol. 28; no. 3; pp. 125 - 133
• Main Authors: Hutmacher, Dietmar W, Loessner, Daniela, Rizzi, Simone, Kaplan, David L, Mooney, David J, Clements, Judith A
• Format: Journal Article
• Language: English
• Published: Cambridge, MA Elsevier Ltd 01.03.2010; [London]: Elsevier Science; Cell Press; Elsevier Limited
• Subjects: Animals; Biological and medical sciences; Bioreactors; Biotechnology; Breast cancer; Extracellular Matrix - pathology; Fundamental and applied biological sciences. Psychology; Health. Pharmaceutical industry; Humans; Industrial applications and implications. Economical aspects; Internal Medicine; Medical research; Miscellaneous; Models, Biological; Neoplasms - pathology; Studies; Tissue Culture Techniques - methods; Tissue engineering; Tissue Engineering - methods; Tissue Scaffolds; In vivo; Bioreactor; Three dimensional culture; Tissue engineering; Tumor; Biology; Models; Review; Scaffold; Hydrogel; Carcinogenesis; In vitro

Advances in tissue engineering have traditionally led to the design of scaffold- or matrix-based culture systems that better reflect the biological, physical and biochemical environment of the natural extracellular matrix. Although their clinical applications in regenerative medicine tend to receive...