Can tissue engineering concepts advance tumor biology research?

Advances in tissue engineering have traditionally led to the design of scaffold- or matrix-based culture systems that better reflect the biological, physical and biochemical environment of the natural extracellular matrix. Although their clinical applications in regenerative medicine tend to receive...

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Published inTrends in biotechnology (Regular ed.) Vol. 28; no. 3; pp. 125 - 133
Main Authors Hutmacher, Dietmar W, Loessner, Daniela, Rizzi, Simone, Kaplan, David L, Mooney, David J, Clements, Judith A
Format Journal Article
LanguageEnglish
Published Cambridge, MA Elsevier Ltd 01.03.2010
[London]: Elsevier Science
Cell Press
Elsevier Limited
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Abstract Advances in tissue engineering have traditionally led to the design of scaffold- or matrix-based culture systems that better reflect the biological, physical and biochemical environment of the natural extracellular matrix. Although their clinical applications in regenerative medicine tend to receive most of the attention, it is obvious that other areas of biomedical research could be well served by the powerful tools that have already been developed in tissue engineering. In this article, we review the recent literature to demonstrate how tissue engineering platforms can enhance in vitro and in vivo models of tumorigenesis and thus hold great promise to contribute to future cancer research.
AbstractList Advances in tissue engineering have traditionally led to the design of scaffold- or matrix-based culture systems that better reflect the biological, physical and biochemical environment of the natural extracellular matrix. Although their clinical applications in regenerative medicine tend to receive most of the attention, it is obvious that other areas of biomedical research could be well served by the powerful tools that have already been developed in tissue engineering. In this article, we review the recent literature to demonstrate how tissue engineering platforms can enhance in vitro and in vivo models of tumorigenesis and thus hold great promise to contribute to future cancer research.
Advances in tissue engineering have traditionally led to the design of scaffold- or matrix-based culture systems that better reflect the biological, physical and biochemical environment of the natural extracellular matrix. Although their clinical applications in regenerative medicine tend to receive most of the attention, it is obvious that other areas of biomedical research could be well served by the powerful tools that have already been developed in tissue engineering. In this article, we review the recent literature to demonstrate how tissue engineering platforms can enhancein vitroandin vivomodels of tumorigenesis and thus hold great promise to contribute to future cancer research.
Advances in tissue engineering have traditionally led to the design of scaffold- or matrix-based culture systems that better reflect the biological, physical and biochemical environment of the natural extracellular matrix. Although their clinical applications in regenerative medicine tend to receive most of the attention, it is obvious that other areas of biomedical research could be well served by the powerful tools that have already been developed in tissue engineering. In this article, we review the recent literature to demonstrate how tissue engineering platforms can enhance in vitro and in vivo models of tumorigenesis and thus hold great promise to contribute to future cancer research.
Author Loessner, Daniela
Mooney, David J
Hutmacher, Dietmar W
Clements, Judith A
Rizzi, Simone
Kaplan, David L
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  fullname: Mooney, David J
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  fullname: Clements, Judith A
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https://www.ncbi.nlm.nih.gov/pubmed/20056286$$D View this record in MEDLINE/PubMed
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Issue 3
Keywords In vivo
Bioreactor
Three dimensional culture
Tissue engineering
Tumor
Biology
Models
Review
Scaffold
Hydrogel
Carcinogenesis
In vitro
Language English
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PublicationTitle Trends in biotechnology (Regular ed.)
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Publisher Elsevier Ltd
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Cell Press
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Snippet Advances in tissue engineering have traditionally led to the design of scaffold- or matrix-based culture systems that better reflect the biological, physical...
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SubjectTerms Animals
Biological and medical sciences
Bioreactors
Biotechnology
Breast cancer
Extracellular Matrix - pathology
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Humans
Industrial applications and implications. Economical aspects
Internal Medicine
Medical research
Miscellaneous
Models, Biological
Neoplasms - pathology
Studies
Tissue Culture Techniques - methods
Tissue engineering
Tissue Engineering - methods
Tissue Scaffolds
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Title Can tissue engineering concepts advance tumor biology research?
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Volume 28
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