Positive and Negative Regulation of Poly(A) Nuclease

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Published inMolecular and Cellular Biology Vol. 24; no. 12; pp. 5521 - 5533
Main Authors Mangus, David A., Evans, Matthew C., Agrin, Nathan S., Smith, Mandy, Gongidi, Preetam, Jacobson, Allan
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.06.2004
Taylor & Francis
Subjects
Amino Acid Sequence
Base Sequence
Binding Sites - genetics
DNA, Fungal - genetics
Exoribonucleases - chemistry
Exoribonucleases - genetics
Exoribonucleases - metabolism
Gene Expression
Genes, Fungal
Models, Molecular
Molecular Sequence Data
Mutation
Peptide Mapping
Poly(A)-Binding Proteins - metabolism
Protein Structure, Tertiary
Protein Subunits
Saccharomyces cerevisiae - enzymology
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - chemistry
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Two-Hybrid System Techniques
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Abstract Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
AbstractList PAN, a yeast poly(A) nuclease, plays an important nuclear role in the posttranscriptional maturation of mRNA poly(A) tails. The activity of this enzyme is dependent on its Pan2p and Pan3p subunits, as well as the presence of poly(A)-binding protein (Pab1p). We have identified and characterized the associated network of factors controlling the maturation of mRNA poly(A) tails in yeast and defined its relevant protein-protein interactions. Pan3p, a positive regulator of PAN activity, interacts with Pab1p, thus providing substrate specificity for this nuclease. Pab1p also regulates poly(A) tail trimming by interacting with Pbp1p, a factor that appears to negatively regulate PAN. Pan3p and Pbp1p both interact with themselves and with the C terminus of Pab1p. However, the domains required for Pan3p and Pbp1p binding on Pab1p are distinct. Single amino acid changes that disrupt Pan3p interaction with Pab1p have been identified and define a binding pocket in helices 2 and 3 of Pab1p's carboxy terminus. The importance of these amino acids for Pab1p-Pan3p interaction, and poly(A) tail regulation, is underscored by experiments demonstrating that strains harboring substitutions in these residues accumulate mRNAs with long poly(A) tails in vivo.
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
Author Nathan S. Agrin
Matthew C. Evans
David A. Mangus
Preetam Gongidi
Mandy Smith
Allan Jacobson
AuthorAffiliation Department of Molecular Genetics and Microbiology University of Massachusetts Medical School, Worcester, Massachusetts 01655
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Present address: Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Corresponding author. Mailing address: Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655. Phone: (508) 856-2442. Fax: (508) 856-5920. E-mail: allan.jacobson@umassmed.edu.
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Snippet Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
PAN, a yeast poly(A) nuclease, plays an important nuclear role in the posttranscriptional maturation of mRNA poly(A) tails. The activity of this enzyme is...
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SubjectTerms Amino Acid Sequence
Base Sequence
Binding Sites - genetics
DNA, Fungal - genetics
Exoribonucleases - chemistry
Exoribonucleases - genetics
Exoribonucleases - metabolism
Gene Expression
Genes, Fungal
Models, Molecular
Molecular Sequence Data
Mutation
Peptide Mapping
Poly(A)-Binding Proteins - metabolism
Protein Structure, Tertiary
Protein Subunits
Saccharomyces cerevisiae - enzymology
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - chemistry
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Two-Hybrid System Techniques
Title Positive and Negative Regulation of Poly(A) Nuclease
URI http://mcb.asm.org/content/24/12/5521.abstract
https://www.tandfonline.com/doi/abs/10.1128/MCB.24.12.5521-5533.2004
https://www.ncbi.nlm.nih.gov/pubmed/15169912
https://search.proquest.com/docview/17979305
https://search.proquest.com/docview/71972076
https://pubmed.ncbi.nlm.nih.gov/PMC419872
Volume 24
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