The interplay between autophagy and the ubiquitin–proteasome system in cardiac proteotoxicity

• Published in: Biochimica et biophysica acta Vol. 1852; no. 2; pp. 188 - 194
• Main Authors: Wang, Changhua, Wang, Xuejun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2015
• Subjects: Autophagy; Autophagy - drug effects; Heart disease; Humans; Models, Biological; Myocardium - metabolism; Myocardium - pathology; Proteasome Endopeptidase Complex - metabolism; Proteins - toxicity; Proteotoxicity; Ubiquitin - metabolism; Ubiquitin–proteasome system; CHF; LAMP-2A; IHD; ALP; Proteotoxicity; I/R; Autophagy; CryAB; HDAC6; GFP; PFI; CHIP; CTSL; UBA; CMA; UPR; Heart disease; UPS; D7-des; UBL; PQC; GFPu; ER; Ub; Ubiquitin–proteasome system; ERAD; GFPdgn; DRC; 3-MA; IPC

Proteotoxicity refers to the detrimental effects of damaged/misfolded proteins on the cell. Cardiac muscle is particularly susceptible to proteotoxicity because sustained and severe proteotoxic stress leads to cell death and the cardiac muscle has very limited self-renewal capacity. The ubiquitin–pr...