Cell death pathologies: targeting death pathways and the immune system for cancer therapy

• Published in: Genes and immunity Vol. 20; no. 7; pp. 539 - 554
• Main Authors: Pentimalli, Francesca, Grelli, Sandro, Di Daniele, Nicola, Melino, Gerry, Amelio, Ivano
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2019; Nature Publishing Group
• Subjects: 631/208/68; 631/250/1933; Analysis; Antimitotic agents; Antineoplastic agents; Apoptosis; Apoptosis - genetics; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Cancer therapies; Care and treatment; Cell death; Cell Death - drug effects; Cell Death - physiology; Entosis; Ferroptosis; Gene Expression; Genes, bcl-2 - genetics; Genes, p53 - genetics; Human Genetics; Humans; Immune response; Immune System; Immunogenicity; Immunology; Immunotherapy; Molecular modelling; Necroptosis; Neoplasms - genetics; Neoplasms - therapy; p53 Protein; Review Article; Signal Transduction; Tumor suppressor genes; Tumors

Alterations in the molecular mechanisms of cell death are a common feature of cancer. These alterations enable malignant cells to survive intrinsic death signalling leading to accumulation of genetic aberrations and helping them to cope with adverse conditions. Regulated cell death has historically...