Amyloid-Beta: A Crucial Factor in Alzheimer's Disease

• Published in: Medical principles and practice Vol. 24; no. 1; pp. 1 - 10
• Main Authors: Sadigh-Eteghad, Saeed, Sabermarouf, Babak, Majdi, Alireza, Talebi, Mahnaz, Farhoudi, Mehdi, Mahmoudi, Javad
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2015
• Subjects: Alzheimer Disease - etiology; Alzheimer Disease - metabolism; Alzheimer Disease - physiopathology; Amyloid beta-Peptides - metabolism; Amyloid beta-Peptides - toxicity; Animals; Biomarkers - blood; Disease Models, Animal; Hippocampus - pathology; Humans; Mice; Plaque, Amyloid - complications; Plaque, Amyloid - pathology; Prions; Review; Pathobiology; Alzheimerߣs disease; Amyloid-beta

Alzheimer's disease (AD) is the most prevalent form of dementia which affects people older than 60 years of age. In AD, the dysregulation of the amyloid-beta (Aβ) level leads to the appearance of senile plaques which contain Aβ depositions. Aβ is a complex biological molecule which interacts wi...