Sonic hedgehog signaling in spinal cord contributes to morphine-induced hyperalgesia and tolerance through upregulating brain-derived neurotrophic factor expression

• Published in: Journal of pain research Vol. 11; pp. 649 - 659
• Main Authors: Liu, Su, Yao, Jun-Li, Wan, Xin-Xin, Song, Zhi-Jing, Miao, Shuai, Zhao, Ye, Wang, Xiu-Li, Liu, Yue-Peng
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2018; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Analgesics; Analysis; Anesthesiology; Antibodies; Brain research; Brain-derived neurotrophic factor; Cancer; Drug dosages; Gene expression; hyperalgesia; Kinases; Laboratory animals; Morphine; Narcotics; Neurons; Original Research; Pain; Response time; RNA; sonic hedgehog; Spinal cord; tolerance; United States > US; China; sonic hedgehog; brain-derived neurotrophic factor; hyperalgesia; spinal cord; tolerance

Preventing opioid-induced hyperalgesia and tolerance continues to be a major clinical challenge, and the underlying mechanisms of hyperalgesia and tolerance remain elusive. Here, we investigated the role of sonic hedgehog (Shh) signaling in opioid-induced hyperalgesia and tolerance. Shh signaling ex...