Gene expression alterations in the medial prefrontal cortex and blood cells in a mouse model of depression during menopause

The prevalence of major depressive disorder (MDD) is higher in women than in men, and this may be due to the decline in estrogen levels that occurs during the menopausal transition. We studied the biological alterations in the medial prefrontal cortex (mPFC), which is a region that is highly implica...

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Published inHeliyon Vol. 2; no. 12; p. e00219
Main Authors Miyata, Shigeo, Kurachi, Masashi, Sakurai, Noriko, Yanagawa, Yuchio, Ishizaki, Yasuki, Mikuni, Masahiko, Fukuda, Masato
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2016
Elsevier
Subjects
Endocrinology
Neuroscience
Psychiatry
Psychiatry
Neuroscience
Endocrinology
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Abstract The prevalence of major depressive disorder (MDD) is higher in women than in men, and this may be due to the decline in estrogen levels that occurs during the menopausal transition. We studied the biological alterations in the medial prefrontal cortex (mPFC), which is a region that is highly implicated in the neurobiology of MDD, and the blood cells (BCs) of ovariectomized (OVX) mice subjected to chronic mild stress (CMS), which represents a mouse model of depression during menopause. The mPFC and the BCs were obtained from the same individuals. Gene expression levels were analyzed by microarray. The data were used for the Ingenuity Pathway Analysis and the Gene Ontology analysis. The gene expression alterations (GEAs) induced by OVX were mainly associated with ribosomal and mitochondrial functions in both the mPFC and the BCs. Rapamycin-insensitive companion of mTOR (RICTOR) was identified as a possible upstream regulator of the OVX-induced GEAs in both tissues. The CMS-induced GEAs were associated with retinoic acid receptor signaling, inflammatory cytokines and post-synaptic density in the mPFC, but not in the BCs. OVX and CMS independently affect biological pathways in the mPFC, which is involved in the development of the depression-like phenotype. Because a subset of the OVX-induced GEAs in the mPFC also occurred in the BCs, the GEAs in the BCs might be a useful probe to predict biological pathways in the corresponding brain tissue under specific conditions such as OVX in females.
AbstractList The prevalence of major depressive disorder (MDD) is higher in women than in men, and this may be due to the decline in estrogen levels that occurs during the menopausal transition. We studied the biological alterations in the medial prefrontal cortex (mPFC), which is a region that is highly implicated in the neurobiology of MDD, and the blood cells (BCs) of ovariectomized (OVX) mice subjected to chronic mild stress (CMS), which represents a mouse model of depression during menopause. The mPFC and the BCs were obtained from the same individuals. Gene expression levels were analyzed by microarray. The data were used for the Ingenuity Pathway Analysis and the Gene Ontology analysis. The gene expression alterations (GEAs) induced by OVX were mainly associated with ribosomal and mitochondrial functions in both the mPFC and the BCs. Rapamycin-insensitive companion of mTOR (RICTOR) was identified as a possible upstream regulator of the OVX-induced GEAs in both tissues. The CMS-induced GEAs were associated with retinoic acid receptor signaling, inflammatory cytokines and post-synaptic density in the mPFC, but not in the BCs. OVX and CMS independently affect biological pathways in the mPFC, which is involved in the development of the depression-like phenotype. Because a subset of the OVX-induced GEAs in the mPFC also occurred in the BCs, the GEAs in the BCs might be a useful probe to predict biological pathways in the corresponding brain tissue under specific conditions such as OVX in females.
AIMSThe prevalence of major depressive disorder (MDD) is higher in women than in men, and this may be due to the decline in estrogen levels that occurs during the menopausal transition. We studied the biological alterations in the medial prefrontal cortex (mPFC), which is a region that is highly implicated in the neurobiology of MDD, and the blood cells (BCs) of ovariectomized (OVX) mice subjected to chronic mild stress (CMS), which represents a mouse model of depression during menopause. MAIN METHODSThe mPFC and the BCs were obtained from the same individuals. Gene expression levels were analyzed by microarray. The data were used for the Ingenuity Pathway Analysis and the Gene Ontology analysis. KEY FINDINGSThe gene expression alterations (GEAs) induced by OVX were mainly associated with ribosomal and mitochondrial functions in both the mPFC and the BCs. Rapamycin-insensitive companion of mTOR (RICTOR) was identified as a possible upstream regulator of the OVX-induced GEAs in both tissues. The CMS-induced GEAs were associated with retinoic acid receptor signaling, inflammatory cytokines and post-synaptic density in the mPFC, but not in the BCs. SIGNIFICANCEOVX and CMS independently affect biological pathways in the mPFC, which is involved in the development of the depression-like phenotype. Because a subset of the OVX-induced GEAs in the mPFC also occurred in the BCs, the GEAs in the BCs might be a useful probe to predict biological pathways in the corresponding brain tissue under specific conditions such as OVX in females.
Aims: The prevalence of major depressive disorder (MDD) is higher in women than in men, and this may be due to the decline in estrogen levels that occurs during the menopausal transition. We studied the biological alterations in the medial prefrontal cortex (mPFC), which is a region that is highly implicated in the neurobiology of MDD, and the blood cells (BCs) of ovariectomized (OVX) mice subjected to chronic mild stress (CMS), which represents a mouse model of depression during menopause. Main methods: The mPFC and the BCs were obtained from the same individuals. Gene expression levels were analyzed by microarray. The data were used for the Ingenuity Pathway Analysis and the Gene Ontology analysis. Key findings: The gene expression alterations (GEAs) induced by OVX were mainly associated with ribosomal and mitochondrial functions in both the mPFC and the BCs. Rapamycin-insensitive companion of mTOR (RICTOR) was identified as a possible upstream regulator of the OVX-induced GEAs in both tissues. The CMS-induced GEAs were associated with retinoic acid receptor signaling, inflammatory cytokines and post-synaptic density in the mPFC, but not in the BCs. Significance: OVX and CMS independently affect biological pathways in the mPFC, which is involved in the development of the depression-like phenotype. Because a subset of the OVX-induced GEAs in the mPFC also occurred in the BCs, the GEAs in the BCs might be a useful probe to predict biological pathways in the corresponding brain tissue under specific conditions such as OVX in females.
ArticleNumber e00222
Author Ishizaki, Yasuki
Yanagawa, Yuchio
Mikuni, Masahiko
Sakurai, Noriko
Kurachi, Masashi
Miyata, Shigeo
Fukuda, Masato
AuthorAffiliation c Department of Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Maebashi, Japan
a Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Japan
b Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Japan
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Cites_doi 10.1016/j.devcel.2006.10.007
10.1016/j.pbb.2015.06.001
10.1210/me.2009-0436
10.1016/j.psyneuen.2007.10.006
10.1016/S0896-6273(02)00653-0
10.1016/j.neuron.2010.12.023
10.1186/1471-2164-11-589
10.1074/jbc.M110.195016
10.7554/eLife.03581
10.1038/emboj.2008.119
10.1016/j.gene.2013.04.018
10.1042/BJ20081668
10.1016/j.pneurobio.2012.05.009
10.1073/pnas.49.3.373
10.1016/j.lfs.2009.01.009
10.3109/10409239409083485
10.1083/jcb.201205030
10.1016/j.lfs.2014.02.014
10.1007/s40263-012-0028-8
10.1074/jbc.M111.304337
10.1016/j.jpsychires.2011.04.008
10.1016/j.cell.2012.03.017
10.1126/scisignal.2001731
10.1038/srep18776
10.1016/j.molcel.2011.03.017
10.1074/jbc.M505553200
10.1016/S0140-6736(12)61680-8
10.1016/j.neuropharm.2012.12.009
10.3325/cmj.2016.57.194
10.1016/j.ijcard.2003.11.046
10.1038/mp.2010.52
10.1146/annurev-med-053013-062946
10.1016/0378-5122(92)90004-N
10.1016/j.lab.2005.10.005
10.1146/annurev.biochem.68.1.913
10.1016/j.maturitas.2008.09.009
10.1016/j.tics.2011.12.011
10.1016/j.yhbeh.2010.07.014
10.1016/j.yhbeh.2004.06.001
10.1016/j.immuni.2010.06.002
10.1016/j.pnpbp.2012.03.003
10.1093/hmg/ddp397
10.1126/science.1106148
10.1128/MCB.00735-09
10.1016/j.neulet.2005.06.048
10.1371/journal.pone.0150262
10.1016/j.biopsych.2005.08.024
10.1073/pnas.47.2.164
10.1097/01.ID.0000116456.76235.BC
10.1016/S1357-2725(98)00128-9
10.1016/S0278-5846(02)00253-1
10.1016/j.neubiorev.2013.07.018
10.1016/j.pnpbp.2007.07.001
10.1038/sj.mp.4002110
10.1038/sj.npp.1300335
10.1016/j.tibs.2016.04.001
10.1002/ajmg.b.31062
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References Glidden, Gray, Vemuru, Li, Harris, Mayo (bib0090) 2012; 287
Bronson, Hillenmeyer, Park, Brodsky (bib0025) 2010; 24
Bremner, McCaffery (bib0020) 2008; 32
Uchida, Hara, Kobayashi, Otsuki, Yamagata, Hobara (bib0285) 2011; 69
Nestler, Barrot, DiLeone, Eisch, Gold, Monteggia (bib0215) 2002; 34
Hamilton (bib0100) 1963; 49
Rocc, De Leo, Eva, Marchiaro, Milani, Musso (bib0240) 2002; 26
Naismith, Norrie, Mowszowski, Hickie (bib0205) 2012; 98
Miller, Yang, Wang, Hargroder, Zhang, Delpire (bib0190) 2014; 3
Iga, Ueno, Yamauchi, Motoki, Tayoshi, Ohta (bib0120) 2005; 389
Gaubitz, Prouteau, Kusmider, Loewith (bib0080) 2016
Carrier, Kabbaj (bib0035) 2013; 70
Saci, Cantley, Carpenter (bib0250) 2011; 42
Abdallah, Sanacora, Duman, Krystal (bib0005) 2015; 66
Kaufert, Gilbert, Tate (bib0145) 2008; 61
Rollins, Martin, Morgan, Vawter (bib0245) 2010; 153b
Cai, Langfelder, Fuller, Oldham, Luo, van den Berg (bib0030) 2010; 11
Sibille, Arango, Galfalvy, Pavlidis, Erraji-Benchekroun, Ellis (bib0275) 2004; 29
Wullschleger, Loewith, Oppliger, Hall (bib0290) 2005; 280
Ferrari, Thomas (bib0065) 1994; 29
Dibble, Asara, Manning (bib0055) 2009; 29
Erburu, Cajaleon, Guruceaga, Venzala, Muñoz-Cobo, Beltrán, Puerta, Tordera (bib0060) 2015; 135
Levinson (bib0175) 2006; 60
Bosker, Gladkevich, Pietersen, Kooi, Bakker, Gerbens (bib0015) 2012; 38
Ivic, Blazetic, Labak, Balog, Vondrak, Blazekovic, Vari, Heffer (bib0130) 2016; 57
Lee, Gudapati, Dragovic, Spencer, Joyce, Killeen (bib0170) 2010; 32
Qi, Zhao, Liu, Fang, Swaab, Zhou (bib0225) 2015; 25
Jasinska, Service, Choi, DeYoung, Grujic, Kong (bib0135) 2009; 18
Klempan, Sequeira, Canetti, Lalovic, Ernst, ffrench-Mullen (bib0155) 2009; 14
Salomon, Vos, Hogan, Gagnon, Naghavi, Mokdad (bib0255) 2012; 380
Cho, Schneider, Krizan, Keller (bib0045) 2004; 13
Guertin, Stevens, Thoreen, Burds, Kalaany, Moffat (bib0095) 2006; 11
Shelton, Claiborne, Sidoryk-Wegrzynowicz, Reddy, Aschner, Lewis (bib0270) 2011; 16
Ikenoue, Inoki, Yang, Zhou, Guan (bib0125) 2008; 27
Laplante, Sabatini (bib0165) 2012; 149
Hunter (bib0115) 1992; 14
Gingras, Raught, Sonenberg (bib0085) 1999; 68
Jechura, Lee (bib0140) 2004; 46
Nakagawasai, Oba, Sato, Arai, Mitazaki, Onogi (bib0210) 2009; 84
Ray, Johnston, Campbell, Nugent, McDade, Waugh (bib0230) 2013; 526
Sarbassov, Guertin, Ali, Sabatini (bib0260) 2005; 307
Chen, Shaikenov, Peterson, Aimbetov, Bissenbaev, Lee (bib0040) 2011; 4
Garcia-Martinez, Alessi (bib0075) 2008; 416
Thomanetz, Angliker, Cloetta, Lustenberger, Schweighauser, Oliveri (bib0280) 2013; 201
Abelaira, Reus, Neotti, Quevedo (bib0010) 2014; 101
Deecher, Andree, Sloan, Schechter (bib0050) 2008; 33
Gan, Wang, Su, Wu (bib0070) 2011; 286
Kimball (bib0150) 1999; 31
Liew, Ma, Tang, Zheng, Dempsey (bib0180) 2006; 147
Mueller, Gorski, Aizawa (bib0200) 1961; 47
Higuchi, Uchida, Yamagata, Otsuki, Hobara, Abe (bib0105) 2011; 45
Price, Drevets (bib0220) 2012; 16
Sato, Yeh (bib0265) 2013; 27
Liu, Xu, Rang, Li, Song (bib0185) 2004; 97
Miyata, Kurachi, Okano, Sakurai, Kobayashi, Harada (bib0195) 2016; 11
Rive, van Rooijen, Veltman, Phillips, Schene, Ruhe (bib0235) 2013; 37
Hori, Sasayama, Teraishi, Yamamoto, Nakamura, Ota (bib0110) 2016; 6
Lagunas, Calmarza-Font, Diz-Chaves, Garcia-Segura (bib0160) 2010; 58
25341010 - Annu Rev Med. 2015;66:509-23
23569215 - J Cell Biol. 2013 Apr 15;201(2):293-308
24582593 - Life Sci. 2014 Apr 17;101(1-2):10-4
17707566 - Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):315-31
23960204 - Cereb Cortex. 2015 Jan;25(1):75-83
23928089 - Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 2):2529-53
21474067 - Mol Cell. 2011 Apr 8;42(1):50-61
26926397 - PLoS One. 2016 Feb 29;11(2):e0150262
22609700 - Prog Neurobiol. 2012 Jul;98 (1):99-143
18566587 - EMBO J. 2008 Jul 23;27(14):1919-31
15561337 - Int J Cardiol. 2004 Dec;97(3):485-93
22197477 - Trends Cogn Sci. 2012 Jan;16(1):61-71
20392875 - Mol Endocrinol. 2010 Jun;24(6):1120-35
20961428 - BMC Genomics. 2010 Oct 20;11:589
21592522 - J Psychiatr Res. 2011 Oct;45(10):1295-300
23245605 - Lancet. 2012 Dec 15;380(9859):2129-43
15325235 - Horm Behav. 2004 Sep;46(3):349-55
20479761 - Mol Psychiatry. 2011 Jul;16(7):751-62
18925875 - Biochem J. 2008 Dec 15;416(3):375-85
19302813 - Life Sci. 2009 Apr 10;84(15-16):512-6
26728011 - Sci Rep. 2016 Jan 05;6:18776
22500797 - Cell. 2012 Apr 13;149(2):274-93
23608168 - Gene. 2013 Aug 15;526(1):46-53
27161823 - Trends Biochem Sci. 2016 Jun;41(6):532-45
14603265 - Neuropsychopharmacology. 2004 Feb;29(2):351-61
13960756 - Proc Natl Acad Sci U S A. 1963 Mar 15;49:373-9
15718470 - Science. 2005 Feb 18;307(5712):1098-101
26051025 - Pharmacol Biochem Behav. 2015 Aug;135:227-36
10216940 - Int J Biochem Cell Biol. 1999 Jan;31(1):25-9
16055263 - Neurosci Lett. 2005 Nov 25;389(1):12-6
20620941 - Immunity. 2010 Jun 25;32(6):743-53
15017309 - Implant Dent. 2004 Mar;13(1):79-87
11931738 - Neuron. 2002 Mar 28;34(1):13-25
19434879 - Maturitas. 2008 Sep-Oct;61(1-2):54-66
20127885 - Am J Med Genet B Neuropsychiatr Genet. 2010 Jun 5;153B(4):919-36
10872469 - Annu Rev Biochem. 1999;68:913-63
19720745 - Mol Cell Biol. 2009 Nov;29(21):5657-70
22084251 - J Biol Chem. 2012 Jan 2;287(1):581-8
16002396 - J Biol Chem. 2005 Sep 2;280(35):30697-704
25340958 - Elife. 2014 Oct 23;3:e03581
7705100 - Crit Rev Biochem Mol Biol. 1994;29(6):385-413
21262472 - Neuron. 2011 Jan 27;69(2):359-72
1565020 - Maturitas. 1992 Jan;14(2):117-26
20691693 - Horm Behav. 2010 Nov;58(5):786-91
27106360 - Croat Med J. 2016 Apr 23;57(2):194-206
18063486 - Psychoneuroendocrinology. 2008 Jan;33(1):3-17
19692348 - Hum Mol Genet. 2009 Nov 15;18(22):4415-27
16300747 - Biol Psychiatry. 2006 Jul 15;60(2):84-92
17938633 - Mol Psychiatry. 2009 Feb;14(2):175-89
22763037 - Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 7;38(2):142-8
23712795 - CNS Drugs. 2013 May;27 Suppl 1:S5-10
21310961 - J Biol Chem. 2011 Apr 1;286(13):10998-1002
17141160 - Dev Cell. 2006 Dec;11(6):859-71
12452539 - Prog Neuropsychopharmacol Biol Psychiatry. 2002 Oct;26(6):1155-60
21343617 - Sci Signal. 2011 Feb 22;4(161):ra10
16503242 - J Lab Clin Med. 2006 Mar;147(3):126-32
13773494 - Proc Natl Acad Sci U S A. 1961 Feb 15;47:164-9
23337256 - Neuropharmacology. 2013 Jul;70:27-34
Ikenoue (10.1016/j.heliyon.2016.e00222_bib0125) 2008; 27
Lagunas (10.1016/j.heliyon.2016.e00222_bib0160) 2010; 58
Mueller (10.1016/j.heliyon.2016.e00222_bib0200) 1961; 47
Cai (10.1016/j.heliyon.2016.e00222_bib0030) 2010; 11
Glidden (10.1016/j.heliyon.2016.e00222_bib0090) 2012; 287
Jasinska (10.1016/j.heliyon.2016.e00222_bib0135) 2009; 18
Chen (10.1016/j.heliyon.2016.e00222_bib0040) 2011; 4
Cho (10.1016/j.heliyon.2016.e00222_bib0045) 2004; 13
Rocc (10.1016/j.heliyon.2016.e00222_bib0240) 2002; 26
Levinson (10.1016/j.heliyon.2016.e00222_bib0175) 2006; 60
Thomanetz (10.1016/j.heliyon.2016.e00222_bib0280) 2013; 201
Sato (10.1016/j.heliyon.2016.e00222_bib0265) 2013; 27
Hunter (10.1016/j.heliyon.2016.e00222_bib0115) 1992; 14
Qi (10.1016/j.heliyon.2016.e00222_bib0225) 2015; 25
Miyata (10.1016/j.heliyon.2016.e00222_bib0195) 2016; 11
Ferrari (10.1016/j.heliyon.2016.e00222_bib0065) 1994; 29
Saci (10.1016/j.heliyon.2016.e00222_bib0250) 2011; 42
Kimball (10.1016/j.heliyon.2016.e00222_bib0150) 1999; 31
Deecher (10.1016/j.heliyon.2016.e00222_bib0050) 2008; 33
Abdallah (10.1016/j.heliyon.2016.e00222_bib0005) 2015; 66
Rollins (10.1016/j.heliyon.2016.e00222_bib0245) 2010; 153b
Hamilton (10.1016/j.heliyon.2016.e00222_bib0100) 1963; 49
Higuchi (10.1016/j.heliyon.2016.e00222_bib0105) 2011; 45
Uchida (10.1016/j.heliyon.2016.e00222_bib0285) 2011; 69
Dibble (10.1016/j.heliyon.2016.e00222_bib0055) 2009; 29
Bosker (10.1016/j.heliyon.2016.e00222_bib0015) 2012; 38
Gaubitz (10.1016/j.heliyon.2016.e00222_bib0080) 2016
Rive (10.1016/j.heliyon.2016.e00222_bib0235) 2013; 37
Ivic (10.1016/j.heliyon.2016.e00222_bib0130) 2016; 57
Liu (10.1016/j.heliyon.2016.e00222_bib0185) 2004; 97
Sibille (10.1016/j.heliyon.2016.e00222_bib0275) 2004; 29
Price (10.1016/j.heliyon.2016.e00222_bib0220) 2012; 16
Iga (10.1016/j.heliyon.2016.e00222_bib0120) 2005; 389
Wullschleger (10.1016/j.heliyon.2016.e00222_bib0290) 2005; 280
Liew (10.1016/j.heliyon.2016.e00222_bib0180) 2006; 147
Klempan (10.1016/j.heliyon.2016.e00222_bib0155) 2009; 14
Hori (10.1016/j.heliyon.2016.e00222_bib0110) 2016; 6
Gingras (10.1016/j.heliyon.2016.e00222_bib0085) 1999; 68
Sarbassov (10.1016/j.heliyon.2016.e00222_bib0260) 2005; 307
Nakagawasai (10.1016/j.heliyon.2016.e00222_bib0210) 2009; 84
Miller (10.1016/j.heliyon.2016.e00222_bib0190) 2014; 3
Naismith (10.1016/j.heliyon.2016.e00222_bib0205) 2012; 98
Erburu (10.1016/j.heliyon.2016.e00222_bib0060) 2015; 135
Bronson (10.1016/j.heliyon.2016.e00222_bib0025) 2010; 24
Nestler (10.1016/j.heliyon.2016.e00222_bib0215) 2002; 34
Abelaira (10.1016/j.heliyon.2016.e00222_bib0010) 2014; 101
Lee (10.1016/j.heliyon.2016.e00222_bib0170) 2010; 32
Jechura (10.1016/j.heliyon.2016.e00222_bib0140) 2004; 46
Kaufert (10.1016/j.heliyon.2016.e00222_bib0145) 2008; 61
Ray (10.1016/j.heliyon.2016.e00222_bib0230) 2013; 526
Garcia-Martinez (10.1016/j.heliyon.2016.e00222_bib0075) 2008; 416
Bremner (10.1016/j.heliyon.2016.e00222_bib0020) 2008; 32
Laplante (10.1016/j.heliyon.2016.e00222_bib0165) 2012; 149
Gan (10.1016/j.heliyon.2016.e00222_bib0070) 2011; 286
Shelton (10.1016/j.heliyon.2016.e00222_bib0270) 2011; 16
Carrier (10.1016/j.heliyon.2016.e00222_bib0035) 2013; 70
Guertin (10.1016/j.heliyon.2016.e00222_bib0095) 2006; 11
Salomon (10.1016/j.heliyon.2016.e00222_bib0255) 2012; 380
References_xml – volume: 11
  start-page: e0150262
  year: 2016
  ident: bib0195
  article-title: Blood transcriptomic markers in patients with late-onset major depressive disorder
  publication-title: PLoS One
  contributor:
    fullname: Harada
– year: 2016
  ident: bib0080
  article-title: TORC2 structure and function
  publication-title: Trends Biochem. Sci.
  contributor:
    fullname: Loewith
– volume: 61
  start-page: 54
  year: 2008
  end-page: 66
  ident: bib0145
  article-title: The Manitoba Project: a re-examination of the link between menopause and depression
  publication-title: Maturitas
  contributor:
    fullname: Tate
– volume: 97
  start-page: 485
  year: 2004
  end-page: 493
  ident: bib0185
  article-title: Influence of ovariectomy and 17beta-estradiol treatment on insulin sensitivity, lipid metabolism and post-ischemic cardiac function
  publication-title: Int. J. Cardiol.
  contributor:
    fullname: Song
– volume: 60
  start-page: 84
  year: 2006
  end-page: 92
  ident: bib0175
  article-title: The genetics of depression: a review
  publication-title: Biol. Psychiatry
  contributor:
    fullname: Levinson
– volume: 25
  start-page: 75
  year: 2015
  end-page: 83
  ident: bib0225
  article-title: Abnormal retinoid and TrkB signaling in the prefrontal cortex in mood disorder
  publication-title: Cereb. Cortex (New York, NY: 1991)
  contributor:
    fullname: Zhou
– volume: 14
  start-page: 175
  year: 2009
  end-page: 189
  ident: bib0155
  article-title: Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression
  publication-title: Mol. Psychiatry
  contributor:
    fullname: ffrench-Mullen
– volume: 11
  start-page: 589
  year: 2010
  ident: bib0030
  article-title: Is human blood a good surrogate for brain tissue in transcriptional studies?
  publication-title: BMC Genomics
  contributor:
    fullname: van den Berg
– volume: 18
  start-page: 4415
  year: 2009
  end-page: 4427
  ident: bib0135
  article-title: Identification of brain transcriptional variation reproduced in peripheral blood: an approach for mapping brain expression traits
  publication-title: Hum. Mol. Genet.
  contributor:
    fullname: Kong
– volume: 149
  start-page: 274
  year: 2012
  end-page: 293
  ident: bib0165
  article-title: mTOR signaling in growth control and disease
  publication-title: Cell
  contributor:
    fullname: Sabatini
– volume: 47
  start-page: 164
  year: 1961
  end-page: 169
  ident: bib0200
  article-title: The role of protein synthesis in early estrogen action
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Aizawa
– volume: 46
  start-page: 349
  year: 2004
  end-page: 355
  ident: bib0140
  article-title: Ovarian hormones influence olfactory cue effects on reentrainment in the diurnal rodent, Octodon degus
  publication-title: Horm. Behav.
  contributor:
    fullname: Lee
– volume: 66
  start-page: 509
  year: 2015
  end-page: 523
  ident: bib0005
  article-title: Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics
  publication-title: Annu. Rev. Med.
  contributor:
    fullname: Krystal
– volume: 27
  start-page: 1919
  year: 2008
  end-page: 1931
  ident: bib0125
  article-title: Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
  publication-title: EMBO J.
  contributor:
    fullname: Guan
– volume: 58
  start-page: 786
  year: 2010
  end-page: 791
  ident: bib0160
  article-title: Long-term ovariectomy enhances anxiety and depressive-like behaviors in mice submitted to chronic unpredictable stress
  publication-title: Horm. Behav.
  contributor:
    fullname: Garcia-Segura
– volume: 38
  start-page: 142
  year: 2012
  end-page: 148
  ident: bib0015
  article-title: Comparison of brain and blood gene expression in an animal model of negative symptoms in schizophrenia
  publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry
  contributor:
    fullname: Gerbens
– volume: 286
  start-page: 10998
  year: 2011
  end-page: 11002
  ident: bib0070
  article-title: Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Wu
– volume: 6
  start-page: 18776
  year: 2016
  ident: bib0110
  article-title: Blood-based gene expression signatures of medication-free outpatients with major depressive disorder: integrative genome-wide and candidate gene analyses
  publication-title: Sci. Rep.
  contributor:
    fullname: Ota
– volume: 32
  start-page: 315
  year: 2008
  end-page: 331
  ident: bib0020
  article-title: The neurobiology of retinoic acid in affective disorders
  publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry
  contributor:
    fullname: McCaffery
– volume: 70
  start-page: 27
  year: 2013
  end-page: 34
  ident: bib0035
  article-title: Sex differences in the antidepressant-like effects of ketamine
  publication-title: Neuropharmacology
  contributor:
    fullname: Kabbaj
– volume: 32
  start-page: 743
  year: 2010
  end-page: 753
  ident: bib0170
  article-title: Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
  publication-title: Immunity
  contributor:
    fullname: Killeen
– volume: 4
  start-page: ra10
  year: 2011
  ident: bib0040
  article-title: ER stress inhibits mTORC2 and Akt signaling through GSK-3beta-mediated phosphorylation of rictor
  publication-title: Sci. Signal.
  contributor:
    fullname: Lee
– volume: 68
  start-page: 913
  year: 1999
  end-page: 963
  ident: bib0085
  article-title: eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation
  publication-title: Annu. Rev. Biochem.
  contributor:
    fullname: Sonenberg
– volume: 33
  start-page: 3
  year: 2008
  end-page: 17
  ident: bib0050
  article-title: From menarche to menopause: exploring the underlying biology of depression in women experiencing hormonal changes
  publication-title: Psychoneuroendocrinology
  contributor:
    fullname: Schechter
– volume: 98
  start-page: 99
  year: 2012
  end-page: 143
  ident: bib0205
  article-title: The neurobiology of depression in later-life: clinical, neuropsychological, neuroimaging and pathophysiological features
  publication-title: Prog. Neurobiol.
  contributor:
    fullname: Hickie
– volume: 49
  start-page: 373
  year: 1963
  end-page: 379
  ident: bib0100
  article-title: Isotopic studies on estrogen-induced accelerations of ribonucleic acid and protein synthesis
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Hamilton
– volume: 280
  start-page: 30697
  year: 2005
  end-page: 30704
  ident: bib0290
  article-title: Molecular organization of target of rapamycin complex 2
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Hall
– volume: 45
  start-page: 1295
  year: 2011
  end-page: 1300
  ident: bib0105
  article-title: State-dependent changes in the expression of DNA methyltransferases in mood disorder patients
  publication-title: J. Psychiatr. Res.
  contributor:
    fullname: Abe
– volume: 16
  start-page: 61
  year: 2012
  end-page: 71
  ident: bib0220
  article-title: Neural circuits underlying the pathophysiology of mood disorders
  publication-title: Trends Cogn. Sci.
  contributor:
    fullname: Drevets
– volume: 27
  start-page: S5
  year: 2013
  end-page: 10
  ident: bib0265
  article-title: Challenges in treating patients with major depressive disorder: the impact of biological and social factors
  publication-title: CNS Drugs
  contributor:
    fullname: Yeh
– volume: 153b
  start-page: 919
  year: 2010
  end-page: 936
  ident: bib0245
  article-title: Analysis of whole genome biomarker expression in blood and brain
  publication-title: Am. J Med. Genet. B Neuropsychiatr. Genet.
  contributor:
    fullname: Vawter
– volume: 29
  start-page: 385
  year: 1994
  end-page: 413
  ident: bib0065
  article-title: S6 phosphorylation and the p70s6k/p85s6k
  publication-title: Crit. Rev. Biochem. Mol. Biol.
  contributor:
    fullname: Thomas
– volume: 287
  start-page: 581
  year: 2012
  end-page: 588
  ident: bib0090
  article-title: Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Mayo
– volume: 57
  start-page: 194
  year: 2016
  end-page: 206
  ident: bib0130
  article-title: Ovariectomy and chronic stress lead toward leptin resistance in the satiety centers and insulin resistance in the hippocampus of Sprague-Dawley rats
  publication-title: Croat. Med. J.
  contributor:
    fullname: Heffer
– volume: 69
  start-page: 359
  year: 2011
  end-page: 372
  ident: bib0285
  article-title: Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events
  publication-title: Neuron
  contributor:
    fullname: Hobara
– volume: 13
  start-page: 79
  year: 2004
  end-page: 87
  ident: bib0045
  article-title: Examination of the bone-implant interface in experimentally induced osteoporotic bone
  publication-title: Implant Dent.
  contributor:
    fullname: Keller
– volume: 101
  start-page: 10
  year: 2014
  end-page: 14
  ident: bib0010
  article-title: The role of mTOR in depression and antidepressant responses
  publication-title: Life Sci.
  contributor:
    fullname: Quevedo
– volume: 3
  start-page: e03581
  year: 2014
  ident: bib0190
  article-title: GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine
  publication-title: eLife
  contributor:
    fullname: Delpire
– volume: 26
  start-page: 1155
  year: 2002
  end-page: 1160
  ident: bib0240
  article-title: Decrease of the D4 dopamine receptor messenger RNA expression in lymphocytes from patients with major depression
  publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry
  contributor:
    fullname: Musso
– volume: 416
  start-page: 375
  year: 2008
  end-page: 385
  ident: bib0075
  article-title: mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
  publication-title: Biochem. J.
  contributor:
    fullname: Alessi
– volume: 526
  start-page: 46
  year: 2013
  end-page: 53
  ident: bib0230
  article-title: Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner
  publication-title: Gene
  contributor:
    fullname: Waugh
– volume: 16
  start-page: 751
  year: 2011
  end-page: 762
  ident: bib0270
  article-title: Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression
  publication-title: Mol. Psychiatry
  contributor:
    fullname: Lewis
– volume: 42
  start-page: 50
  year: 2011
  end-page: 61
  ident: bib0250
  article-title: Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
  publication-title: Mol. Cell
  contributor:
    fullname: Carpenter
– volume: 11
  start-page: 859
  year: 2006
  end-page: 871
  ident: bib0095
  article-title: Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
  publication-title: Dev. Cell
  contributor:
    fullname: Moffat
– volume: 147
  start-page: 126
  year: 2006
  end-page: 132
  ident: bib0180
  article-title: The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool
  publication-title: J. Lab. Clin. Med.
  contributor:
    fullname: Dempsey
– volume: 24
  start-page: 1120
  year: 2010
  end-page: 1135
  ident: bib0025
  article-title: Estrogen coordinates translation and transcription, revealing a role for NRSF in human breast cancer cells
  publication-title: Mol. Endocrinol.
  contributor:
    fullname: Brodsky
– volume: 29
  start-page: 5657
  year: 2009
  end-page: 5670
  ident: bib0055
  article-title: Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
  publication-title: Mol. Cell. Biol.
  contributor:
    fullname: Manning
– volume: 84
  start-page: 512
  year: 2009
  end-page: 516
  ident: bib0210
  article-title: Subchronic stress-induced depressive behavior in ovariectomized mice
  publication-title: Life Sci.
  contributor:
    fullname: Onogi
– volume: 29
  start-page: 351
  year: 2004
  end-page: 361
  ident: bib0275
  article-title: Gene expression profiling of depression and suicide in human prefrontal cortex
  publication-title: Neuropsychopharmacology
  contributor:
    fullname: Ellis
– volume: 14
  start-page: 117
  year: 1992
  end-page: 126
  ident: bib0115
  article-title: The south-east England longitudinal study of the climacteric and postmenopause
  publication-title: Maturitas
  contributor:
    fullname: Hunter
– volume: 389
  start-page: 12
  year: 2005
  end-page: 16
  ident: bib0120
  article-title: Serotonin transporter mRNA expression in peripheral leukocytes of patients with major depression before and after treatment with paroxetine
  publication-title: Neurosci. Lett.
  contributor:
    fullname: Ohta
– volume: 135
  start-page: 227
  year: 2015
  end-page: 236
  ident: bib0060
  article-title: Chronic mild stress and imipramine treatment elicit opposite changes in behavior and in gene expression in the mouse prefrontal cortex
  publication-title: Pharmacol. Biochem. Behav.
  contributor:
    fullname: Tordera
– volume: 37
  start-page: 2529
  year: 2013
  end-page: 2553
  ident: bib0235
  article-title: Neural correlates of dysfunctional emotion regulation in major depressive disorder: a systematic review of neuroimaging studies
  publication-title: Neurosci. Biobehav. Rev.
  contributor:
    fullname: Ruhe
– volume: 307
  start-page: 1098
  year: 2005
  end-page: 1101
  ident: bib0260
  article-title: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR comple
  publication-title: Science (New York, NY)
  contributor:
    fullname: Sabatini
– volume: 34
  start-page: 13
  year: 2002
  end-page: 25
  ident: bib0215
  article-title: Neurobiology of depression
  publication-title: Neuron
  contributor:
    fullname: Monteggia
– volume: 201
  start-page: 293
  year: 2013
  end-page: 308
  ident: bib0280
  article-title: Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology
  publication-title: J. Cell Biol.
  contributor:
    fullname: Oliveri
– volume: 31
  start-page: 25
  year: 1999
  end-page: 29
  ident: bib0150
  article-title: Eukaryotic initiation factor eIF2
  publication-title: Int. J. Biochem. Cell Biol.
  contributor:
    fullname: Kimball
– volume: 380
  start-page: 2129
  year: 2012
  end-page: 2143
  ident: bib0255
  article-title: Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010
  publication-title: Lancet
  contributor:
    fullname: Mokdad
– volume: 11
  start-page: 859
  year: 2006
  ident: 10.1016/j.heliyon.2016.e00222_bib0095
  article-title: Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2006.10.007
  contributor:
    fullname: Guertin
– volume: 135
  start-page: 227
  issue: August
  year: 2015
  ident: 10.1016/j.heliyon.2016.e00222_bib0060
  article-title: Chronic mild stress and imipramine treatment elicit opposite changes in behavior and in gene expression in the mouse prefrontal cortex
  publication-title: Pharmacol. Biochem. Behav.
  doi: 10.1016/j.pbb.2015.06.001
  contributor:
    fullname: Erburu
– volume: 24
  start-page: 1120
  issue: 6
  year: 2010
  ident: 10.1016/j.heliyon.2016.e00222_bib0025
  article-title: Estrogen coordinates translation and transcription, revealing a role for NRSF in human breast cancer cells
  publication-title: Mol. Endocrinol.
  doi: 10.1210/me.2009-0436
  contributor:
    fullname: Bronson
– volume: 33
  start-page: 3
  year: 2008
  ident: 10.1016/j.heliyon.2016.e00222_bib0050
  article-title: From menarche to menopause: exploring the underlying biology of depression in women experiencing hormonal changes
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2007.10.006
  contributor:
    fullname: Deecher
– volume: 34
  start-page: 13
  year: 2002
  ident: 10.1016/j.heliyon.2016.e00222_bib0215
  article-title: Neurobiology of depression
  publication-title: Neuron
  doi: 10.1016/S0896-6273(02)00653-0
  contributor:
    fullname: Nestler
– volume: 69
  start-page: 359
  year: 2011
  ident: 10.1016/j.heliyon.2016.e00222_bib0285
  article-title: Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events
  publication-title: Neuron
  doi: 10.1016/j.neuron.2010.12.023
  contributor:
    fullname: Uchida
– volume: 11
  start-page: 589
  year: 2010
  ident: 10.1016/j.heliyon.2016.e00222_bib0030
  article-title: Is human blood a good surrogate for brain tissue in transcriptional studies?
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-11-589
  contributor:
    fullname: Cai
– volume: 286
  start-page: 10998
  year: 2011
  ident: 10.1016/j.heliyon.2016.e00222_bib0070
  article-title: Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.195016
  contributor:
    fullname: Gan
– volume: 3
  start-page: e03581
  year: 2014
  ident: 10.1016/j.heliyon.2016.e00222_bib0190
  article-title: GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine
  publication-title: eLife
  doi: 10.7554/eLife.03581
  contributor:
    fullname: Miller
– volume: 27
  start-page: 1919
  year: 2008
  ident: 10.1016/j.heliyon.2016.e00222_bib0125
  article-title: Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
  publication-title: EMBO J.
  doi: 10.1038/emboj.2008.119
  contributor:
    fullname: Ikenoue
– volume: 526
  start-page: 46
  issue: 1
  year: 2013
  ident: 10.1016/j.heliyon.2016.e00222_bib0230
  article-title: Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner
  publication-title: Gene
  doi: 10.1016/j.gene.2013.04.018
  contributor:
    fullname: Ray
– volume: 416
  start-page: 375
  year: 2008
  ident: 10.1016/j.heliyon.2016.e00222_bib0075
  article-title: mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
  publication-title: Biochem. J.
  doi: 10.1042/BJ20081668
  contributor:
    fullname: Garcia-Martinez
– volume: 98
  start-page: 99
  year: 2012
  ident: 10.1016/j.heliyon.2016.e00222_bib0205
  article-title: The neurobiology of depression in later-life: clinical, neuropsychological, neuroimaging and pathophysiological features
  publication-title: Prog. Neurobiol.
  doi: 10.1016/j.pneurobio.2012.05.009
  contributor:
    fullname: Naismith
– volume: 49
  start-page: 373
  year: 1963
  ident: 10.1016/j.heliyon.2016.e00222_bib0100
  article-title: Isotopic studies on estrogen-induced accelerations of ribonucleic acid and protein synthesis
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.49.3.373
  contributor:
    fullname: Hamilton
– volume: 84
  start-page: 512
  year: 2009
  ident: 10.1016/j.heliyon.2016.e00222_bib0210
  article-title: Subchronic stress-induced depressive behavior in ovariectomized mice
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2009.01.009
  contributor:
    fullname: Nakagawasai
– volume: 29
  start-page: 385
  year: 1994
  ident: 10.1016/j.heliyon.2016.e00222_bib0065
  article-title: S6 phosphorylation and the p70s6k/p85s6k
  publication-title: Crit. Rev. Biochem. Mol. Biol.
  doi: 10.3109/10409239409083485
  contributor:
    fullname: Ferrari
– volume: 201
  start-page: 293
  year: 2013
  ident: 10.1016/j.heliyon.2016.e00222_bib0280
  article-title: Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201205030
  contributor:
    fullname: Thomanetz
– volume: 101
  start-page: 10
  year: 2014
  ident: 10.1016/j.heliyon.2016.e00222_bib0010
  article-title: The role of mTOR in depression and antidepressant responses
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2014.02.014
  contributor:
    fullname: Abelaira
– volume: 27
  start-page: S5
  issue: Suppl. 1
  year: 2013
  ident: 10.1016/j.heliyon.2016.e00222_bib0265
  article-title: Challenges in treating patients with major depressive disorder: the impact of biological and social factors
  publication-title: CNS Drugs
  doi: 10.1007/s40263-012-0028-8
  contributor:
    fullname: Sato
– volume: 287
  start-page: 581
  year: 2012
  ident: 10.1016/j.heliyon.2016.e00222_bib0090
  article-title: Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.304337
  contributor:
    fullname: Glidden
– volume: 45
  start-page: 1295
  year: 2011
  ident: 10.1016/j.heliyon.2016.e00222_bib0105
  article-title: State-dependent changes in the expression of DNA methyltransferases in mood disorder patients
  publication-title: J. Psychiatr. Res.
  doi: 10.1016/j.jpsychires.2011.04.008
  contributor:
    fullname: Higuchi
– volume: 149
  start-page: 274
  year: 2012
  ident: 10.1016/j.heliyon.2016.e00222_bib0165
  article-title: mTOR signaling in growth control and disease
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.017
  contributor:
    fullname: Laplante
– volume: 4
  start-page: ra10
  year: 2011
  ident: 10.1016/j.heliyon.2016.e00222_bib0040
  article-title: ER stress inhibits mTORC2 and Akt signaling through GSK-3beta-mediated phosphorylation of rictor
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.2001731
  contributor:
    fullname: Chen
– volume: 6
  start-page: 18776
  year: 2016
  ident: 10.1016/j.heliyon.2016.e00222_bib0110
  article-title: Blood-based gene expression signatures of medication-free outpatients with major depressive disorder: integrative genome-wide and candidate gene analyses
  publication-title: Sci. Rep.
  doi: 10.1038/srep18776
  contributor:
    fullname: Hori
– volume: 42
  start-page: 50
  year: 2011
  ident: 10.1016/j.heliyon.2016.e00222_bib0250
  article-title: Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2011.03.017
  contributor:
    fullname: Saci
– volume: 280
  start-page: 30697
  year: 2005
  ident: 10.1016/j.heliyon.2016.e00222_bib0290
  article-title: Molecular organization of target of rapamycin complex 2
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M505553200
  contributor:
    fullname: Wullschleger
– volume: 380
  start-page: 2129
  year: 2012
  ident: 10.1016/j.heliyon.2016.e00222_bib0255
  article-title: Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010
  publication-title: Lancet
  doi: 10.1016/S0140-6736(12)61680-8
  contributor:
    fullname: Salomon
– volume: 70
  start-page: 27
  year: 2013
  ident: 10.1016/j.heliyon.2016.e00222_bib0035
  article-title: Sex differences in the antidepressant-like effects of ketamine
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2012.12.009
  contributor:
    fullname: Carrier
– volume: 57
  start-page: 194
  issue: April (2)
  year: 2016
  ident: 10.1016/j.heliyon.2016.e00222_bib0130
  article-title: Ovariectomy and chronic stress lead toward leptin resistance in the satiety centers and insulin resistance in the hippocampus of Sprague-Dawley rats
  publication-title: Croat. Med. J.
  doi: 10.3325/cmj.2016.57.194
  contributor:
    fullname: Ivic
– volume: 97
  start-page: 485
  year: 2004
  ident: 10.1016/j.heliyon.2016.e00222_bib0185
  article-title: Influence of ovariectomy and 17beta-estradiol treatment on insulin sensitivity, lipid metabolism and post-ischemic cardiac function
  publication-title: Int. J. Cardiol.
  doi: 10.1016/j.ijcard.2003.11.046
  contributor:
    fullname: Liu
– volume: 16
  start-page: 751
  year: 2011
  ident: 10.1016/j.heliyon.2016.e00222_bib0270
  article-title: Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2010.52
  contributor:
    fullname: Shelton
– volume: 66
  start-page: 509
  year: 2015
  ident: 10.1016/j.heliyon.2016.e00222_bib0005
  article-title: Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics
  publication-title: Annu. Rev. Med.
  doi: 10.1146/annurev-med-053013-062946
  contributor:
    fullname: Abdallah
– volume: 14
  start-page: 117
  year: 1992
  ident: 10.1016/j.heliyon.2016.e00222_bib0115
  article-title: The south-east England longitudinal study of the climacteric and postmenopause
  publication-title: Maturitas
  doi: 10.1016/0378-5122(92)90004-N
  contributor:
    fullname: Hunter
– volume: 147
  start-page: 126
  year: 2006
  ident: 10.1016/j.heliyon.2016.e00222_bib0180
  article-title: The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool
  publication-title: J. Lab. Clin. Med.
  doi: 10.1016/j.lab.2005.10.005
  contributor:
    fullname: Liew
– volume: 68
  start-page: 913
  year: 1999
  ident: 10.1016/j.heliyon.2016.e00222_bib0085
  article-title: eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev.biochem.68.1.913
  contributor:
    fullname: Gingras
– volume: 61
  start-page: 54
  year: 2008
  ident: 10.1016/j.heliyon.2016.e00222_bib0145
  article-title: The Manitoba Project: a re-examination of the link between menopause and depression
  publication-title: Maturitas
  doi: 10.1016/j.maturitas.2008.09.009
  contributor:
    fullname: Kaufert
– volume: 16
  start-page: 61
  year: 2012
  ident: 10.1016/j.heliyon.2016.e00222_bib0220
  article-title: Neural circuits underlying the pathophysiology of mood disorders
  publication-title: Trends Cogn. Sci.
  doi: 10.1016/j.tics.2011.12.011
  contributor:
    fullname: Price
– volume: 58
  start-page: 786
  year: 2010
  ident: 10.1016/j.heliyon.2016.e00222_bib0160
  article-title: Long-term ovariectomy enhances anxiety and depressive-like behaviors in mice submitted to chronic unpredictable stress
  publication-title: Horm. Behav.
  doi: 10.1016/j.yhbeh.2010.07.014
  contributor:
    fullname: Lagunas
– volume: 46
  start-page: 349
  issue: September (3)
  year: 2004
  ident: 10.1016/j.heliyon.2016.e00222_bib0140
  article-title: Ovarian hormones influence olfactory cue effects on reentrainment in the diurnal rodent, Octodon degus
  publication-title: Horm. Behav.
  doi: 10.1016/j.yhbeh.2004.06.001
  contributor:
    fullname: Jechura
– volume: 32
  start-page: 743
  year: 2010
  ident: 10.1016/j.heliyon.2016.e00222_bib0170
  article-title: Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
  publication-title: Immunity
  doi: 10.1016/j.immuni.2010.06.002
  contributor:
    fullname: Lee
– volume: 38
  start-page: 142
  year: 2012
  ident: 10.1016/j.heliyon.2016.e00222_bib0015
  article-title: Comparison of brain and blood gene expression in an animal model of negative symptoms in schizophrenia
  publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2012.03.003
  contributor:
    fullname: Bosker
– volume: 18
  start-page: 4415
  year: 2009
  ident: 10.1016/j.heliyon.2016.e00222_bib0135
  article-title: Identification of brain transcriptional variation reproduced in peripheral blood: an approach for mapping brain expression traits
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddp397
  contributor:
    fullname: Jasinska
– volume: 307
  start-page: 1098
  year: 2005
  ident: 10.1016/j.heliyon.2016.e00222_bib0260
  article-title: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR comple
  publication-title: Science (New York, NY)
  doi: 10.1126/science.1106148
  contributor:
    fullname: Sarbassov
– volume: 29
  start-page: 5657
  year: 2009
  ident: 10.1016/j.heliyon.2016.e00222_bib0055
  article-title: Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00735-09
  contributor:
    fullname: Dibble
– volume: 389
  start-page: 12
  year: 2005
  ident: 10.1016/j.heliyon.2016.e00222_bib0120
  article-title: Serotonin transporter mRNA expression in peripheral leukocytes of patients with major depression before and after treatment with paroxetine
  publication-title: Neurosci. Lett.
  doi: 10.1016/j.neulet.2005.06.048
  contributor:
    fullname: Iga
– volume: 11
  start-page: e0150262
  year: 2016
  ident: 10.1016/j.heliyon.2016.e00222_bib0195
  article-title: Blood transcriptomic markers in patients with late-onset major depressive disorder
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0150262
  contributor:
    fullname: Miyata
– volume: 60
  start-page: 84
  year: 2006
  ident: 10.1016/j.heliyon.2016.e00222_bib0175
  article-title: The genetics of depression: a review
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2005.08.024
  contributor:
    fullname: Levinson
– volume: 47
  start-page: 164
  year: 1961
  ident: 10.1016/j.heliyon.2016.e00222_bib0200
  article-title: The role of protein synthesis in early estrogen action
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.47.2.164
  contributor:
    fullname: Mueller
– volume: 13
  start-page: 79
  year: 2004
  ident: 10.1016/j.heliyon.2016.e00222_bib0045
  article-title: Examination of the bone-implant interface in experimentally induced osteoporotic bone
  publication-title: Implant Dent.
  doi: 10.1097/01.ID.0000116456.76235.BC
  contributor:
    fullname: Cho
– volume: 31
  start-page: 25
  year: 1999
  ident: 10.1016/j.heliyon.2016.e00222_bib0150
  article-title: Eukaryotic initiation factor eIF2
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/S1357-2725(98)00128-9
  contributor:
    fullname: Kimball
– volume: 25
  start-page: 75
  year: 2015
  ident: 10.1016/j.heliyon.2016.e00222_bib0225
  article-title: Abnormal retinoid and TrkB signaling in the prefrontal cortex in mood disorder
  publication-title: Cereb. Cortex (New York, NY: 1991)
  contributor:
    fullname: Qi
– volume: 26
  start-page: 1155
  year: 2002
  ident: 10.1016/j.heliyon.2016.e00222_bib0240
  article-title: Decrease of the D4 dopamine receptor messenger RNA expression in lymphocytes from patients with major depression
  publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry
  doi: 10.1016/S0278-5846(02)00253-1
  contributor:
    fullname: Rocc
– volume: 37
  start-page: 2529
  year: 2013
  ident: 10.1016/j.heliyon.2016.e00222_bib0235
  article-title: Neural correlates of dysfunctional emotion regulation in major depressive disorder: a systematic review of neuroimaging studies
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2013.07.018
  contributor:
    fullname: Rive
– volume: 32
  start-page: 315
  year: 2008
  ident: 10.1016/j.heliyon.2016.e00222_bib0020
  article-title: The neurobiology of retinoic acid in affective disorders
  publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2007.07.001
  contributor:
    fullname: Bremner
– volume: 14
  start-page: 175
  year: 2009
  ident: 10.1016/j.heliyon.2016.e00222_bib0155
  article-title: Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression
  publication-title: Mol. Psychiatry
  doi: 10.1038/sj.mp.4002110
  contributor:
    fullname: Klempan
– volume: 29
  start-page: 351
  year: 2004
  ident: 10.1016/j.heliyon.2016.e00222_bib0275
  article-title: Gene expression profiling of depression and suicide in human prefrontal cortex
  publication-title: Neuropsychopharmacology
  doi: 10.1038/sj.npp.1300335
  contributor:
    fullname: Sibille
– year: 2016
  ident: 10.1016/j.heliyon.2016.e00222_bib0080
  article-title: TORC2 structure and function
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2016.04.001
  contributor:
    fullname: Gaubitz
– volume: 153b
  start-page: 919
  year: 2010
  ident: 10.1016/j.heliyon.2016.e00222_bib0245
  article-title: Analysis of whole genome biomarker expression in blood and brain
  publication-title: Am. J Med. Genet. B Neuropsychiatr. Genet.
  doi: 10.1002/ajmg.b.31062
  contributor:
    fullname: Rollins
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Snippet The prevalence of major depressive disorder (MDD) is higher in women than in men, and this may be due to the decline in estrogen levels that occurs during the...
AIMSThe prevalence of major depressive disorder (MDD) is higher in women than in men, and this may be due to the decline in estrogen levels that occurs during...
Aims: The prevalence of major depressive disorder (MDD) is higher in women than in men, and this may be due to the decline in estrogen levels that occurs...
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Title Gene expression alterations in the medial prefrontal cortex and blood cells in a mouse model of depression during menopause
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