Viral Endomyocardial Infection Is an Independent Predictor and Potentially Treatable Risk Factor for Graft Loss and Coronary Vasculopathy in Pediatric Cardiac Transplant Recipients

• Published in: Journal of the American College of Cardiology Vol. 56; no. 7; pp. 582 - 592
• Main Authors: Moulik, Mousumi, MD, Breinholt, John P., MD, Dreyer, William J., MD, Kearney, Debra L., MD, Price, Jack F., MD, Clunie, Sarah K., RN, Moffett, Brady S., PharmD, Kim, Jeffrey J., MD, Rossano, Joseph W., MD, Jefferies, John Lynn, MD, MPH, Bowles, Karla R., PhD, O'Brian Smith, E., PhD, Bowles, Neil E., PhD, Denfield, Susan W., MD, Towbin, Jeffrey A., MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 10.08.2010; Elsevier; Elsevier Limited
• Subjects: Adenovirus; Adolescent; Biological and medical sciences; Biopsy; cardiac transplantation; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Child; Child, Preschool; Coronary Disease - virology; Coronary heart disease; Cytomegalovirus; Female; Genome, Viral; Graft Rejection - virology; Graft Survival; graft vasculopathy; Heart; Heart Transplantation; Humans; Infant; Infant, Newborn; Infections; Infectious diseases; Internal Medicine; Male; Medical sciences; Myocarditis - epidemiology; Myocarditis - virology; outcome; Polymerase Chain Reaction; Prevalence; Risk Factors; TCAD; Transplants & implants; Viral diseases; Viral infections; virus; graft vasculopathy; cardiac transplantation; IVIG; transplant coronary artery disease; virus; CMV; ISHLT; AR; acute rejection; cytomegalovirus; TCAD; EBV; endomyocardial biopsy; International Society of Heart and Lung Transplantation; Epstein-Barr virus; EMB; intravenous immunoglobulin; outcome; PCR; polymerase chain reaction; Human; Heart; Pediatrics; Predictor; Coronary artery; Loss; Cardiovascular disease; Transplantation; Homotransplantation; Coronary heart disease; Infection; Vascular disease; Treatment; Surgery; Viral disease; Risk factor; Graft; Circulatory system; Cardiology; Predictive factor; Child

Objectives This study sought to evaluate the outcome and prevalence of viral endomyocardial infection after cardiac transplantation. Background Viral myocardial infection causes heart failure, but its role after cardiac transplantation is unclear. We hypothesized that viral infection of the cardiac...