Transcriptome Alterations in Prefrontal Pyramidal Cells Distinguish Schizophrenia From Bipolar and Major Depressive Disorders

• Published in: Biological psychiatry (1969) Vol. 82; no. 8; pp. 594 - 600
• Main Authors: Arion, Dominique, Huo, Zhiguang, Enwright, John F., Corradi, John P., Tseng, George, Lewis, David A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.10.2017
• Subjects: Adult; Bipolar disorder; Bipolar Disorder - diagnosis; Depressive Disorder, Major - diagnosis; Female; Gene Expression Profiling; Humans; Laser Capture Microdissection; Major depression; Male; Microarray; Microarray Analysis; Middle Aged; Prefrontal cortex; Prefrontal Cortex - pathology; Psychiatric/Mental Health; Pyramidal Cells - metabolism; Pyramidal neurons; Reproducibility of Results; RNA, Messenger - metabolism; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - pathology; Severity of Illness Index; Signal Transduction - physiology; Transcriptome - physiology; Schizophrenia; Bipolar disorder; Prefrontal cortex; Microarray; Pyramidal neurons; Major depression

Impairments in certain cognitive processes (e.g., working memory) are typically most pronounced in schizophrenia (SZ), intermediate in bipolar disorder, and least in major depressive disorder. Given that working memory depends, in part, on neural circuitry that includes pyramidal cells in layer 3 (L...