Epigenetic programming underpins B cell dysfunction in human SLE

• Published in: Nature immunology Vol. 20; no. 8; pp. 1071 - 1082
• Main Authors: Scharer, Christopher D., Blalock, Emily L., Mi, Tian, Barwick, Benjamin G., Jenks, Scott A., Deguchi, Tsuneo, Cashman, Kevin S., Neary, Bridget E., Patterson, Dillon G., Hicks, Sakeenah L., Khosroshahi, Arezou, Eun-Hyung Lee, F., Wei, Chungwen, Sanz, Iñaki, Boss, Jeremy M.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.08.2019; Nature Publishing Group
• Subjects: 631/250/1619/40; 631/250/2502/2170; 631/250/38; Activator protein 1; Analysis; Autoantibodies; B cells; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - pathology; Biomedical and Life Sciences; Biomedicine; Care and treatment; Cell differentiation; Chromatin; Chromatin Assembly and Disassembly - physiology; DNA Methylation - genetics; Early Growth Response Transcription Factors - genetics; Effector cells; Epigenesis, Genetic - genetics; Epigenetic inheritance; Epigenetics; Genetic aspects; Genome-wide association studies; Humans; Immunological memory; Immunology; Infectious Diseases; Lupus; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Lymphocytes B; Memory cells; Plasma cells; Systemic lupus erythematosus; Transcription Factor AP-1 - genetics; Transcription factors; Transcriptome - genetics

Systemic lupus erythematosus (SLE) is characterized by the expansion of extrafollicular pathogenic B cells derived from newly activated naive cells. Although these cells express distinct markers, their epigenetic architecture and how it contributes to SLE remain poorly understood. To address this, w...