Exercise Augmentation of Exposure Therapy for PTSD: Rationale and Pilot Efficacy Data

Brain-derived neurotrophic factor (BDNF) is associated with synaptic plasticity, which is crucial for long-term learning and memory. Some studies suggest that people suffering from anxiety disorders show reduced BDNF relative to healthy controls. Lower BDNF is associated with impaired learning, cogn...

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Published inCognitive behaviour therapy Vol. 44; no. 4; pp. 314 - 327
Main Authors Powers, Mark B., Medina, Johnna L., Burns, Stephanie, Kauffman, Brooke Y., Monfils, Marie, Asmundson, Gordon J.G., Diamond, Allison, McIntyre, Christa, Smits, Jasper A.J.
Format Journal Article
LanguageEnglish
Published England Routledge 01.01.2015
Taylor & Francis Ltd
Subjects
Adult
anxiety disorders
augmentation
BDNF
Brain-Derived Neurotrophic Factor - blood
CBT
Cognitive therapy
Combined Modality Therapy - methods
Exercise
Exercise - psychology
Exercise Therapy - methods
exposure therapy
Female
Humans
Implosive Therapy - methods
Male
pilot data
Pilot Projects
Post traumatic stress disorder
Stress Disorders, Post-Traumatic - blood
Stress Disorders, Post-Traumatic - therapy
Young Adult
CBT
BDNF
exercise
anxiety disorders
exposure therapy
pilot data
augmentation
Online AccessGet full text

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Abstract Brain-derived neurotrophic factor (BDNF) is associated with synaptic plasticity, which is crucial for long-term learning and memory. Some studies suggest that people suffering from anxiety disorders show reduced BDNF relative to healthy controls. Lower BDNF is associated with impaired learning, cognitive deficits, and poor exposure-based treatment outcomes. A series of studies with rats showed that exercise elevates BDNF and enhances fear extinction. However, this strategy has not been tested in humans. In this pilot study, we randomized participants (N = 9, 8 females, M Age  = 34) with posttraumatic stress disorder (PTSD) to (a) prolonged exposure alone (PE) or (b) prolonged exposure+exercise (PE+E). Participants randomized to the PE+E condition completed a 30-minute bout of moderate-intensity treadmill exercise (70% of age-predicted HR max ) prior to each PE session. Consistent with prediction, the PE+E group showed a greater improvement in PTSD symptoms (d = 2.65) and elevated BDNF (d = 1.08) relative to the PE only condition. This pilot study provides initial support for further investigation into exercise augmented exposure therapy.
AbstractList Brain-derived neurotrophic factor (BDNF) is associated with synaptic plasticity, which is crucial for long-term learning and memory. Some studies suggest that people suffering from anxiety disorders show reduced BDNF relative to healthy controls. Lower BDNF is associated with impaired learning, cognitive deficits, and poor exposure-based treatment outcomes. A series of studies with rats showed that exercise elevates BDNF and enhances fear extinction. However, this strategy has not been tested in humans. In this pilot study, we randomized participants (N = 9, 8 females, M... = 34) with posttraumatic stress disorder (PTSD) to (a) prolonged exposure alone (PE) or (b) prolonged exposure+exercise (PE+E). Participants randomized to the PE+E condition completed a 30-minute bout of moderate-intensity treadmill exercise (70% of age-predicted HR...) prior to each PE session. Consistent with prediction, the PE+E group showed a greater improvement in PTSD symptoms (d = 2.65) and elevated BDNF (d = 1.08) relative to the PE only condition. This pilot study provides initial support for further investigation into exercise augmented exposure therapy. (ProQuest: ... denotes formulae/symbols omitted.)
Brain-derived neurotrophic factor (BDNF) is associated with synaptic plasticity, which is crucial for long-term learning and memory. Some studies suggest that people suffering from anxiety disorders show reduced BDNF relative to healthy controls. Lower BDNF is associated with impaired learning, cognitive deficits, and poor exposure-based treatment outcomes. A series of studies with rats showed that exercise elevates BDNF and enhances fear extinction. However, this strategy has not been tested in humans. In this pilot study, we randomized participants ( N = 9, 8 females, M Age = 34) with posttraumatic stress disorder (PTSD) to (a) prolonged exposure alone (PE) or (b) prolonged exposure + exercise (PE + E). Participants randomized to the PE + E condition completed a 30-minute bout of moderate-intensity treadmill exercise (70% of age-predicted HR max ) prior to each PE session. Consistent with prediction, the PE + E group showed a greater improvement in PTSD symptoms ( d = 2.65) and elevated BDNF ( d = 1.08) relative to the PE only condition. This pilot study provides initial support for further investigation into exercise augmented exposure therapy.
Brain-derived neurotrophic factor (BDNF) is associated with synaptic plasticity, which is crucial for long-term learning and memory. Some studies suggest that people suffering from anxiety disorders show reduced BDNF relative to healthy controls. Lower BDNF is associated with impaired learning, cognitive deficits, and poor exposure-based treatment outcomes. A series of studies with rats showed that exercise elevates BDNF and enhances fear extinction. However, this strategy has not been tested in humans. In this pilot study, we randomized participants (N = 9, 8 females, M(Age) = 34) with posttraumatic stress disorder (PTSD) to (a) prolonged exposure alone (PE) or (b) prolonged exposure+exercise (PE+E). Participants randomized to the PE+E condition completed a 30-minute bout of moderate-intensity treadmill exercise (70% of age-predicted HR(max)) prior to each PE session. Consistent with prediction, the PE+E group showed a greater improvement in PTSD symptoms (d = 2.65) and elevated BDNF (d = 1.08) relative to the PE only condition. This pilot study provides initial support for further investigation into exercise augmented exposure therapy.
Brain-derived neurotrophic factor (BDNF) is associated with synaptic plasticity, which is crucial for long-term learning and memory. Some studies suggest that people suffering from anxiety disorders show reduced BDNF relative to healthy controls. Lower BDNF is associated with impaired learning, cognitive deficits, and poor exposure-based treatment outcomes. A series of studies with rats showed that exercise elevates BDNF and enhances fear extinction. However, this strategy has not been tested in humans. In this pilot study, we randomized participants (N = 9, 8 females, M Age  = 34) with posttraumatic stress disorder (PTSD) to (a) prolonged exposure alone (PE) or (b) prolonged exposure+exercise (PE+E). Participants randomized to the PE+E condition completed a 30-minute bout of moderate-intensity treadmill exercise (70% of age-predicted HR max ) prior to each PE session. Consistent with prediction, the PE+E group showed a greater improvement in PTSD symptoms (d = 2.65) and elevated BDNF (d = 1.08) relative to the PE only condition. This pilot study provides initial support for further investigation into exercise augmented exposure therapy.
Author Asmundson, Gordon J.G.
McIntyre, Christa
Kauffman, Brooke Y.
Smits, Jasper A.J.
Monfils, Marie
Powers, Mark B.
Diamond, Allison
Burns, Stephanie
Medina, Johnna L.
AuthorAffiliation 2 Department of Psychology, University of Regina, Regina, Canada
3 School of Behavioral Health and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA
1 Department of Psychology, Institute for Mental Health Research, The University of Texas at Austin, Austin, TX, USA
AuthorAffiliation_xml – name: 3 School of Behavioral Health and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA
– name: 2 Department of Psychology, University of Regina, Regina, Canada
– name: 1 Department of Psychology, Institute for Mental Health Research, The University of Texas at Austin, Austin, TX, USA
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  surname: Powers
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  email: mbpowers@utexas.edu
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– sequence: 2
  givenname: Johnna L.
  surname: Medina
  fullname: Medina, Johnna L.
  organization: Department of Psychology, Institute for Mental Health Research, The University of Texas at Austin
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  fullname: Burns, Stephanie
  organization: Department of Psychology, Institute for Mental Health Research, The University of Texas at Austin
– sequence: 4
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  surname: Kauffman
  fullname: Kauffman, Brooke Y.
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  fullname: Monfils, Marie
  organization: Department of Psychology, Institute for Mental Health Research, The University of Texas at Austin
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  surname: Asmundson
  fullname: Asmundson, Gordon J.G.
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  givenname: Allison
  surname: Diamond
  fullname: Diamond, Allison
  organization: Department of Psychology, Institute for Mental Health Research, The University of Texas at Austin
– sequence: 8
  givenname: Christa
  surname: McIntyre
  fullname: McIntyre, Christa
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– sequence: 9
  givenname: Jasper A.J.
  surname: Smits
  fullname: Smits, Jasper A.J.
  organization: Department of Psychology, Institute for Mental Health Research, The University of Texas at Austin
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25706090$$D View this record in MEDLINE/PubMed
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IngestDate Tue Sep 17 21:14:28 EDT 2024
Fri Oct 25 04:19:07 EDT 2024
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Wed Oct 16 00:57:45 EDT 2024
Tue Jun 13 19:57:34 EDT 2023
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Issue 4
Keywords CBT
BDNF
exercise
anxiety disorders
exposure therapy
pilot data
augmentation
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Snippet Brain-derived neurotrophic factor (BDNF) is associated with synaptic plasticity, which is crucial for long-term learning and memory. Some studies suggest that...
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StartPage 314
SubjectTerms Adult
anxiety disorders
augmentation
BDNF
Brain-Derived Neurotrophic Factor - blood
CBT
Cognitive therapy
Combined Modality Therapy - methods
Exercise
Exercise - psychology
Exercise Therapy - methods
exposure therapy
Female
Humans
Implosive Therapy - methods
Male
pilot data
Pilot Projects
Post traumatic stress disorder
Stress Disorders, Post-Traumatic - blood
Stress Disorders, Post-Traumatic - therapy
Young Adult
Title Exercise Augmentation of Exposure Therapy for PTSD: Rationale and Pilot Efficacy Data
URI https://www.tandfonline.com/doi/abs/10.1080/16506073.2015.1012740
https://www.ncbi.nlm.nih.gov/pubmed/25706090
https://www.proquest.com/docview/1699267571
https://search.proquest.com/docview/1687641880
https://pubmed.ncbi.nlm.nih.gov/PMC4464974
Volume 44
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