Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models

• Published in: Psychopharmacologia Vol. 220; no. 4; pp. 647 - 672
• Main Authors: Lyon, L., Saksida, L. M., Bussey, T. J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.04.2012; Springer; Springer Nature B.V
• Subjects: Acetylcholine receptors; Acetylcholine receptors (muscarinic); Adult and adolescent clinical studies; Animal behavior; Animal cognition; Animal memory; Animal models; Animals; Antipsychotic Agents - therapeutic use; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cannabinoids; Cognition Disorders - drug therapy; Cognition Disorders - genetics; Cognition Disorders - pathology; Cognitive ability; Communications equipment; Data collections; Disease Models, Animal; Dopamine; Drugs; GABA; gamma -Aminobutyric acid; Genetically modified organisms; Glutamate; Glutamic acid; Humans; Immune response; Medical sciences; Memory; Mental disorders; Mice; neuregulin; Neurosciences; Pattern recognition; Pharmacology/Toxicology; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Psychoses; Rats; Recognition (Psychology) - drug effects; Recognition (Psychology) - physiology; Review; Reviews; Rodentia; Rodents; Schizophrenia; Schizophrenia - drug therapy; Schizophrenia - genetics; Schizophrenia - pathology; Serotonin S6 receptors; Species Specificity; Time Factors; Translation; Novel; Dopamine; Memory; Schizophrenia; Neuregulin; Spontaneous object recognition; Glutamate; COMT; Animal model; Enzyme; Transferases; Catechol O-methyltransferase; Review; Catecholamine; Psychosis; Methyltransferases; Animal; Excitatory aminoacid; Neurotransmitter; Development; Genetics; Lesion; Recognition

Rationale Spontaneous (novel) object recognition (SOR) is one of the most widely used rodent behavioural tests. The opportunity for rapid data collection has made SOR a popular choice in studies that explore cognitive impairment in rodent models of schizophrenia, and that test the efficacy of drugs...