Alteration of CD1 expression in multiple sclerosis

• Published in: Clinical and experimental immunology Vol. 169; no. 1; pp. 10 - 16
• Main Authors: Bine, S., Haziot, A., Malikova, I., Pelletier, J., Charron, D., Boucraut, J., Mooney, N., Gelin, C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2012; Blackwell; Oxford University Press; Wiley
• Subjects: Adult; Aged; Analytical, structural and metabolic biochemistry; Antigen Presentation; Antigens, CD1 - biosynthesis; autoimmunity; Biological and medical sciences; dendritic cells; Dendritic Cells - immunology; Female; Fundamental and applied biological sciences. Psychology; Humans; Lipids; Lipids - immunology; Male; Medical sciences; Middle Aged; monocytes; Monocytes - immunology; Multiple sclerosis; Multiple Sclerosis - immunology; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Myeloid Cells - immunology; Neurology; Original; serum; Autoimmunity; Dendritic cell; monocytes; Nervous system diseases; Multiple sclerosis; dendritic cells; Monocyte; Antigen presenting cell; Central nervous system disease; Serum; Biochemistry; Inflammatory disease; Antigens; Humans; Middle Aged; Male; Myeloid Cells/immunology; Antigen Presentation; Monocytes/immunology; Adult; CD1/biosynthesis; Female; Aged; Dendritic Cells/immunology; Lipids/immunology; Multiple Sclerosis/immunology
• DOI: 10.1111/j.1365-2249.2012.04586.x
• ISSN: 0009-9104

Summary Studies of multiple sclerosis (MS) have concentrated mainly on antigen presentation of peptides derived from the myelin sheath, while the implication of lipid antigen has been less explored in this pathology. As the extracellular environment regulates expression of the lipid antigen‐presenting molecule CD1, we have examined whether sera from patients alters CD1 surface expression in monocyte‐derived dendritic cells. We have shown that: (i) CD1 group 1 proteins were highly expressed in the presence of MS sera; (ii) sera from MS patients differentially regulated CD1 group 1 versus CD1 group 2 molecular expression; and (iii) CD1 was expressed strongly in monocytes from MS patients under immunosuppressive treatment. Overall, these results reveal that CD1 expression is modified in MS and provide novel information on the regulation of lipid antigen presentation in myeloid cells.