A NEW MEDIUM‐TERM BIOASSAY SYSTEM FOR DETECTION OF ENVIRONMENTAL CARCINOGENS USING DIETHYLNITROSAMINE‐INITIATED RAT LIVER FOLLOWED BY D‐GALACTOSAMINE TREATMENT AND PARTIAL HEPATECTOMY

The effects of D‐galactosamine on induction of preneoplastic glutathione S‐transferase placental form positive liver foci were investigated in F344 rats pretreated with diethylnitrosamine (DEN) in an attempt to improve the predictive value of the medium‐term bioassay system developed in our laborato...

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Published inCancer science Vol. 79; no. 5; pp. 573 - 575
Main Authors Ito, Nobuyuki, Imaida, Katsumi, Camargo, Joao Lauro V., Takahashi, Satoru, Asamoto, Makoto, Tsuda, Hiroyuki
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.05.1988
Japanese Cancer Association
John Wiley & Sons, Inc
Subjects
Animals
Bioassays
Biological and medical sciences
Biological Assay - methods
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens
Carcinogens - analysis
Chemical agents
D-Galactosamine
Diethylnitrosamine
Galactosamine - pharmacology
Glutathione
Glutathione Transferase - metabolism
GST‐P
Hepatectomy
Injection
Liver
Liver Neoplasms - chemically induced
Male
Medical sciences
Medium‐term bioassay
Partial hepatectomy
Placenta
Rapid Communication
Rat liver
Rats
Rats, Inbred F344
Tumors
Galactosamine
Potentiation
Premalignant lesion
Tumor initiator
Rat
Induction
Liver
Nitrosamine
Rodentia
Tumoral marker
Biological method
Carcinogen
Vertebrata
Mammalia
Glutathione transferase
Animal
Experimental tumor
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Abstract The effects of D‐galactosamine on induction of preneoplastic glutathione S‐transferase placental form positive liver foci were investigated in F344 rats pretreated with diethylnitrosamine (DEN) in an attempt to improve the predictive value of the medium‐term bioassay system developed in our laboratory. Two weeks after the initial single ip dose (200 mg/kg) of DEN, administration of test compounds was commenced simultaneously with an ip injection of D‐galactosamine at a dose of 300 mg/kg body wt. All rats were then subjected to two‐thirds partial hepatectomy (PH) at week 5 and sacrificed for assessment of lesion yield at week 8. Measurement and comparison of the numbers and areas of glutathione S‐transferase placental form positive (GST‐P+) foci per cm2 revealed a positive response to more carcinogens, including non‐hepatocarcinogens, than did the same bioassay system without injection of D‐galactosamine. Thus the results suggest that inclusion of this extra proliferative stimulus may improve the medium‐term detection of carcinogens and modifiers.
AbstractList The effects of D‐galactosamine on induction of preneoplastic glutathione S‐transferase placental form positive liver foci were investigated in F344 rats pretreated with diethylnitrosamine (DEN) in an attempt to improve the predictive value of the medium‐term bioassay system developed in our laboratory. Two weeks after the initial single ip dose (200 mg/kg) of DEN, administration of test compounds was commenced simultaneously with an ip injection of D‐galactosamine at a dose of 300 mg/kg body wt. All rats were then subjected to two‐thirds partial hepatectomy (PH) at week 5 and sacrificed for assessment of lesion yield at week 8. Measurement and comparison of the numbers and areas of glutathione S‐transferase placental form positive (GST‐P + ) foci per cm 2 revealed a positive response to more carcinogens, including non‐hepatocarcinogens, than did the same bioassay system without injection of D‐galactosamine. Thus the results suggest that inclusion of this extra proliferative stimulus may improve the medium‐term detection of carcinogens and modifiers.
The effects of D‐galactosamine on induction of preneoplastic glutathione S‐transferase placental form positive liver foci were investigated in F344 rats pretreated with diethylnitrosamine (DEN) in an attempt to improve the predictive value of the medium‐term bioassay system developed in our laboratory. Two weeks after the initial single ip dose (200 mg/kg) of DEN, administration of test compounds was commenced simultaneously with an ip injection of D‐galactosamine at a dose of 300 mg/kg body wt. All rats were then subjected to two‐thirds partial hepatectomy (PH) at week 5 and sacrificed for assessment of lesion yield at week 8. Measurement and comparison of the numbers and areas of glutathione S‐transferase placental form positive (GST‐P+) foci per cm2 revealed a positive response to more carcinogens, including non‐hepatocarcinogens, than did the same bioassay system without injection of D‐galactosamine. Thus the results suggest that inclusion of this extra proliferative stimulus may improve the medium‐term detection of carcinogens and modifiers.
Author Ito, Nobuyuki
Camargo, Joao Lauro V.
Takahashi, Satoru
Imaida, Katsumi
Tsuda, Hiroyuki
Asamoto, Makoto
AuthorAffiliation 1 First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho‐cho, Mizuho‐ku, Nagoya 467
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  fullname: Asamoto, Makoto
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  fullname: Tsuda, Hiroyuki
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10.1073/pnas.82.12.3964
10.1093/carcin/9.3.387
10.1111/j.1349-7006.1988.tb01606.x
10.1177/019262338701500107
10.1016/0014-4800(68)90042-7
10.1177/019262338501300402
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Issue 5
Keywords Galactosamine
Potentiation
Premalignant lesion
Tumor initiator
Rat
Induction
Liver
Nitrosamine
Rodentia
Tumoral marker
Biological method
Carcinogen
Vertebrata
Mammalia
Glutathione transferase
Animal
Experimental tumor
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PublicationTitle Cancer science
PublicationTitleAlternate Jpn J Cancer Res
PublicationYear 1988
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Japanese Cancer Association
John Wiley & Sons, Inc
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The effects of D-galactosamine on induction of preneoplastic glutathione S-transferase placental form positive liver foci were investigated in F344 rats...
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StartPage 573
SubjectTerms Animals
Bioassays
Biological and medical sciences
Biological Assay - methods
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens
Carcinogens - analysis
Chemical agents
D-Galactosamine
Diethylnitrosamine
Galactosamine - pharmacology
Glutathione
Glutathione Transferase - metabolism
GST‐P
Hepatectomy
Injection
Liver
Liver Neoplasms - chemically induced
Male
Medical sciences
Medium‐term bioassay
Partial hepatectomy
Placenta
Rapid Communication
Rat liver
Rats
Rats, Inbred F344
Tumors
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Title A NEW MEDIUM‐TERM BIOASSAY SYSTEM FOR DETECTION OF ENVIRONMENTAL CARCINOGENS USING DIETHYLNITROSAMINE‐INITIATED RAT LIVER FOLLOWED BY D‐GALACTOSAMINE TREATMENT AND PARTIAL HEPATECTOMY
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1349-7006.1988.tb00023.x
https://www.ncbi.nlm.nih.gov/pubmed/3136108
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https://pubmed.ncbi.nlm.nih.gov/PMC5917556
Volume 79
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