A NEW MEDIUM‐TERM BIOASSAY SYSTEM FOR DETECTION OF ENVIRONMENTAL CARCINOGENS USING DIETHYLNITROSAMINE‐INITIATED RAT LIVER FOLLOWED BY D‐GALACTOSAMINE TREATMENT AND PARTIAL HEPATECTOMY
The effects of D‐galactosamine on induction of preneoplastic glutathione S‐transferase placental form positive liver foci were investigated in F344 rats pretreated with diethylnitrosamine (DEN) in an attempt to improve the predictive value of the medium‐term bioassay system developed in our laborato...
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Published in | Cancer science Vol. 79; no. 5; pp. 573 - 575 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.05.1988
Japanese Cancer Association John Wiley & Sons, Inc |
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Abstract | The effects of D‐galactosamine on induction of preneoplastic glutathione S‐transferase placental form positive liver foci were investigated in F344 rats pretreated with diethylnitrosamine (DEN) in an attempt to improve the predictive value of the medium‐term bioassay system developed in our laboratory. Two weeks after the initial single ip dose (200 mg/kg) of DEN, administration of test compounds was commenced simultaneously with an ip injection of D‐galactosamine at a dose of 300 mg/kg body wt. All rats were then subjected to two‐thirds partial hepatectomy (PH) at week 5 and sacrificed for assessment of lesion yield at week 8. Measurement and comparison of the numbers and areas of glutathione S‐transferase placental form positive (GST‐P+) foci per cm2 revealed a positive response to more carcinogens, including non‐hepatocarcinogens, than did the same bioassay system without injection of D‐galactosamine. Thus the results suggest that inclusion of this extra proliferative stimulus may improve the medium‐term detection of carcinogens and modifiers. |
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AbstractList | The effects of D‐galactosamine on induction of preneoplastic glutathione S‐transferase placental form positive liver foci were investigated in F344 rats pretreated with diethylnitrosamine (DEN) in an attempt to improve the predictive value of the medium‐term bioassay system developed in our laboratory. Two weeks after the initial single ip dose (200 mg/kg) of DEN, administration of test compounds was commenced simultaneously with an ip injection of D‐galactosamine at a dose of 300 mg/kg body wt. All rats were then subjected to two‐thirds partial hepatectomy (PH) at week 5 and sacrificed for assessment of lesion yield at week 8. Measurement and comparison of the numbers and areas of glutathione S‐transferase placental form positive (GST‐P
+
) foci per cm
2
revealed a positive response to more carcinogens, including non‐hepatocarcinogens, than did the same bioassay system without injection of D‐galactosamine. Thus the results suggest that inclusion of this extra proliferative stimulus may improve the medium‐term detection of carcinogens and modifiers. The effects of D‐galactosamine on induction of preneoplastic glutathione S‐transferase placental form positive liver foci were investigated in F344 rats pretreated with diethylnitrosamine (DEN) in an attempt to improve the predictive value of the medium‐term bioassay system developed in our laboratory. Two weeks after the initial single ip dose (200 mg/kg) of DEN, administration of test compounds was commenced simultaneously with an ip injection of D‐galactosamine at a dose of 300 mg/kg body wt. All rats were then subjected to two‐thirds partial hepatectomy (PH) at week 5 and sacrificed for assessment of lesion yield at week 8. Measurement and comparison of the numbers and areas of glutathione S‐transferase placental form positive (GST‐P+) foci per cm2 revealed a positive response to more carcinogens, including non‐hepatocarcinogens, than did the same bioassay system without injection of D‐galactosamine. Thus the results suggest that inclusion of this extra proliferative stimulus may improve the medium‐term detection of carcinogens and modifiers. |
Author | Ito, Nobuyuki Camargo, Joao Lauro V. Takahashi, Satoru Imaida, Katsumi Tsuda, Hiroyuki Asamoto, Makoto |
AuthorAffiliation | 1 First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho‐cho, Mizuho‐ku, Nagoya 467 |
AuthorAffiliation_xml | – name: 1 First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho‐cho, Mizuho‐ku, Nagoya 467 |
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Cites_doi | 10.1016/0304-3835(87)90159-5 10.1073/pnas.82.12.3964 10.1093/carcin/9.3.387 10.1111/j.1349-7006.1988.tb01606.x 10.1177/019262338701500107 10.1016/0014-4800(68)90042-7 10.1177/019262338501300402 |
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Keywords | Galactosamine Potentiation Premalignant lesion Tumor initiator Rat Induction Liver Nitrosamine Rodentia Tumoral marker Biological method Carcinogen Vertebrata Mammalia Glutathione transferase Animal Experimental tumor |
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References | 1986 1968; 9 1984; 75 1988; 79 1972 1985; 82 1988; 9 1987; 15 1985; 13 1987; 37 e_1_2_1_7_2 e_1_2_1_4_2 e_1_2_1_5_2 e_1_2_1_11_2 e_1_2_1_3_2 e_1_2_1_10_2 Decker K. (e_1_2_1_9_2) 1972 Montesano R. (e_1_2_1_2_2) 1986 Tsuda H. (e_1_2_1_6_2) 1984; 75 e_1_2_1_8_2 |
References_xml | – volume: 75 start-page: 876 year: 1984 end-page: 883 article-title: Modifying potential of thirty‐one chemicals on the short‐term development of γ‐glutamyl transpeptidase‐positive foci in diethylnitrosamineinitiated rat liver publication-title: Gann – year: 1986 – start-page: 183 year: 1972 end-page: 199 – volume: 37 start-page: 163 year: 1987 end-page: 171 article-title: Compared promoting potential of D‐galactosamine, carbon tetrachloride and partial hepatectomy in rapid induction of preneoplastic liver lesions in the rat publication-title: Cancer Lett. – volume: 9 start-page: 387 year: 1988 end-page: 394 article-title: Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S‐transferase placental form positive foci in rats—an approach for a new medium‐term bioassay system publication-title: Carcinogenesis – volume: 82 start-page: 3964 year: 1985 end-page: 3968 article-title: Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical carcinogenesis publication-title: Proc. Natl. Acad. Sci. USA – volume: 9 start-page: 279 year: 1968 end-page: 290 article-title: Experimental hepatitis induced by D‐galactosamine publication-title: Exp. Mol. Pathol. – volume: 15 start-page: 60 year: 1987 end-page: 68 article-title: Placental glutathione S‐transferase (GST‐P) as a new marker for hepatocarcinogenesis: short‐term screening for hepatocarcinogens publication-title: Toxicol. Pathol. – volume: 79 start-page: 413 year: 1988 end-page: 417 article-title: Wide‐spectrum initiation models: possible applications to medium‐term multiple organ bioassays for carcinogenesis modifiers publication-title: Jpn. J. Cancer Res. (Gann) – volume: 13 start-page: 257 year: 1985 end-page: 265 article-title: Comparison of dose dependent effects of chemical carcinogens on induction of glutathione S‐transferase placental form positive liver foci in a short term assay and of hepatocellular carcinomas in a long‐term assay publication-title: Toxicol. Pathol. – ident: e_1_2_1_11_2 doi: 10.1016/0304-3835(87)90159-5 – volume-title: Long‐term and Short‐term Assays for Carcinogens: a Critical Appraisal year: 1986 ident: e_1_2_1_2_2 contributor: fullname: Montesano R. – ident: e_1_2_1_4_2 doi: 10.1073/pnas.82.12.3964 – ident: e_1_2_1_7_2 doi: 10.1093/carcin/9.3.387 – ident: e_1_2_1_8_2 doi: 10.1111/j.1349-7006.1988.tb01606.x – ident: e_1_2_1_3_2 doi: 10.1177/019262338701500107 – start-page: 183 volume-title: Progress in Liver Diseases year: 1972 ident: e_1_2_1_9_2 contributor: fullname: Decker K. – ident: e_1_2_1_10_2 doi: 10.1016/0014-4800(68)90042-7 – ident: e_1_2_1_5_2 doi: 10.1177/019262338501300402 – volume: 75 start-page: 876 year: 1984 ident: e_1_2_1_6_2 article-title: Modifying potential of thirty‐one chemicals on the short‐term development of γ‐glutamyl transpeptidase‐positive foci in diethylnitrosamineinitiated rat liver publication-title: Gann contributor: fullname: Tsuda H. |
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Snippet | The effects of D‐galactosamine on induction of preneoplastic glutathione S‐transferase placental form positive liver foci were investigated in F344 rats... The effects of D-galactosamine on induction of preneoplastic glutathione S-transferase placental form positive liver foci were investigated in F344 rats... |
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SubjectTerms | Animals Bioassays Biological and medical sciences Biological Assay - methods Carcinogenesis, carcinogens and anticarcinogens Carcinogens Carcinogens - analysis Chemical agents D-Galactosamine Diethylnitrosamine Galactosamine - pharmacology Glutathione Glutathione Transferase - metabolism GST‐P Hepatectomy Injection Liver Liver Neoplasms - chemically induced Male Medical sciences Medium‐term bioassay Partial hepatectomy Placenta Rapid Communication Rat liver Rats Rats, Inbred F344 Tumors |
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Title | A NEW MEDIUM‐TERM BIOASSAY SYSTEM FOR DETECTION OF ENVIRONMENTAL CARCINOGENS USING DIETHYLNITROSAMINE‐INITIATED RAT LIVER FOLLOWED BY D‐GALACTOSAMINE TREATMENT AND PARTIAL HEPATECTOMY |
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